Transducin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 8: Line 8:
== Disease ==
== Disease ==
Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.
Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.
 +
==3D structures of transducin==
 +
[[Transducin 3D structures]]
</StructureSection>
</StructureSection>
Line 24: Line 26:
**[[1fqk]] – bTDN + RGS9 + GDP + AlF4<br />
**[[1fqk]] – bTDN + RGS9 + GDP + AlF4<br />
**[[1fqj]] – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4<br />
**[[1fqj]] – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4<br />
 +
 +
*Transducin-β
 +
 +
**[[6n9g]] – TDN + RGS7 - mouse<br />
*Transducin-βγ
*Transducin-βγ
 +
**[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />
 +
**[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
 +
**[[6m8s]] – hTDN + KCTD12<br />
 +
**[[6nbi]], [[6nbh]], [[6nbf]] – hTDN + PTH/PTHRP + long-acting parathyroid hormone + GS protein a subunit + nanobody – Cryo EM<br />
 +
**[[4pnk]] – h/bTDN + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />
**[[1tbg]] – bTDN <br />
**[[1tbg]] – bTDN <br />
**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
Line 32: Line 43:
**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />
**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />
**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />
**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />
-
**[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />
 
-
**[[4pnk]] – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />
 
**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />
**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />
**[[3uzs]] – bTDN + β-adrenergic receptor kinase 1 + RNA<br />
**[[3uzs]] – bTDN + β-adrenergic receptor kinase 1 + RNA<br />
-
**[[3krw]], [[3krx]] – bTDN + G-protein coupled receptor kinase 2 + inhibitor<br />
+
**[[3krw]], [[3krx]], [[6c2y]], [[5wg5]], [[5wg4]], [[5wg3]] – bTDN + G-protein coupled receptor kinase 2 + inhibitor<br />
**[[1xhm]] – bTDN + peptide<br />
**[[1xhm]] – bTDN + peptide<br />
-
**[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
+
**[[6pcv]] – bTDN + RAC exchanger – Cryo EM<br />
 +
**[[6b20]] – bTDN + nanobody<br />
*Transducin-α+βγ
*Transducin-α+βγ
 +
**[[6eg8]] – hTDN + GDP<br />
 +
**[[6ddf]], [[6dde]] – hTDN + mu opioid receptor + DAMGO – Cryo EM<br />
 +
**[[6d9h]] – hTDN + AChR/adenosine receptor – Cryo EM<br />
 +
**[[6p9x]] – hTDN + CRFR-1 + corticliberin – Cryo EM<br />
 +
**[[6osa]] – hTDN + NTR1 + JMV449 – Cryo EM<br />
 +
**[[6g79]] – hTDN + serotonin receptor – Cryo EM<br />
 +
**[[6oy9]] – bTDN + rhodopsin + retinal – Cryo EM<br />
 +
**[[6oya]] – bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
**[[1got]] – bTDN + GDP<br />
**[[1got]] – bTDN + GDP<br />
-
**[[1gg2]] – TDN rα (mutant) + bβγ + GDP - rat<br />
+
**[[1gp2]], [[5kdo]], [[1gg2]] – r/bTDN + GDP - rat<br />
-
**[[1gp2]], [[5kdo]] – TDN rα + bβγ + GDP <br />
+
**[[3ah8]] – r/bTDN (mutant) + GDP + inhibitor<br />
-
**[[3ah8]] – TDN rα + bβ + bγ (mutant) + GDP + inhibitor<br />
+
**[[5tdh]] – h/r/bTDN (mutant) + GDP<br />
-
**[[3sn6]] – TDN bα (mutant) + rβ (mutant) +bγ + endolysine + antibody fragment<br />
+
 
-
**[[5tdh]] – TDN hα (mutant) + rβ + bγ + GDP<br />
+
*Transducin-α+βγ complex with antibody
 +
 
 +
**[[6pt0]], [[6n4b]], [[6kpg]], [[6kpf]] – hTDN + cannaboid receptor + antibody fragment – Cryo EM<br />
 +
**[[6pb1]], [[6pb0]] – hTDN + CRFR-2 + urocortin + nanobody – Cryo EM<br />
 +
**[[6os9]] – hTDN + NTR1 + JMV449 + antibody fragment – Cryo EM<br />
 +
**[[6oik]], [[6oij]] – hTDN + AChR + antibody fragment – Cryo EM<br />
 +
**[[6crk]] – hTDN + antibody fragment <br />
 +
**[[6niy]], [[6e3y]] – hTDN + calcitonin receptor + calcitonin + nanobody – Cryo EM<br />
**[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br />
**[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br />
-
**[[5vai]] – TDN hα + rβ + bγ+ glucagon-like peptide + antibody fragment - Cryo EM<br />
+
**[[6ni3]] – hTDN + endolysin/adrenergic receptor + nanobody – Cryo EM<br />
 +
**[[6omm]] – hTDN + formyl peptide receptor + peptide agonist + antibody fragment – Cryo EM<br />
 +
**[[6p9y]] – hTDN + PACAP + nanobody – Cryo EM<br />
 +
**[[6li3]] – hTDN + GPR52 + nanobody – Cryo EM<br />
 +
**[[6gdg]] – hTDN + adenosine A2A receptor + nanobody – Cryo EM<br />
 +
**[[6b3j]] – hTDN + GLP-1R + exendin-p5 + nanobody – Cryo EM<br />
 +
**[[6ot0]] – hTDN + antibody + smoothened homolog – Cryo EM<br />
 +
**[[6cmo]] – hTDN + antibody + rhodopsin/cytochrome b562 – Cryo EM<br />
 +
**[[6qno]] – h/bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
 +
**[[5vai]] – h/r/bTDN + glucagon-like peptide + antibody fragment - Cryo EM<br />
 +
**[[3sn6]] – TDN ba (mutant) + rb (mutant) + bc + endolysine + antibody fragment<br />
 +
 
}}
}}
== References ==
== References ==

Revision as of 08:18, 5 March 2020

Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code 1gp2).

Drag the structure with the mouse to rotate

3D structures of transducin

Updated on 05-March-2020

References

  1. ↑ Lerea CL, Bunt-Milam AH, Hurley JB. Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina. Neuron. 1989 Sep;3(3):367-76. PMID:2534964
  2. ↑ Dryja TP, Hahn LB, Reboul T, Arnaud B. Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness. Nat Genet. 1996 Jul;13(3):358-60. PMID:8673138 doi:http://dx.doi.org/10.1038/ng0796-358

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Transducin"
Personal tools