3j7q
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Structure of the idle mammalian ribosome-Sec61 complex== | ==Structure of the idle mammalian ribosome-Sec61 complex== | ||
| - | < | + | <SX load='3j7q' size='340' side='right' viewer='molstar' caption='[[3j7q]], [[Resolution|resolution]] 3.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3j7q]] is a 48 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4w24 4w24], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4w25 4w25], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwy 1vwy], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwz 1vwz] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j72 3j72]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[3j7q]] is a 48 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4w24 4w24], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4w25 4w25], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwy 1vwy], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vwz 1vwz] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j72 3j72]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7Q FirstGlance]. <br> | ||
| Line 10: | Line 10: | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/RL34_PIG RL34_PIG]] Component of the large ribosomal subunit.<ref>PMID:24930395</ref> [[http://www.uniprot.org/uniprot/RL21_PIG RL21_PIG]] Component of the large ribosomal subunit.<ref>PMID:24930395</ref> [[http://www.uniprot.org/uniprot/RL11_PIG RL11_PIG]] Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity). [[http://www.uniprot.org/uniprot/RL40_PIG RL40_PIG]] Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). 60S ribosomal protein L40: component of the 60S subunit of the ribosome (By similarity). [[http://www.uniprot.org/uniprot/RL10_PIG RL10_PIG]] Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.[UniProtKB:P27635] [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/RL34_PIG RL34_PIG]] Component of the large ribosomal subunit.<ref>PMID:24930395</ref> [[http://www.uniprot.org/uniprot/RL21_PIG RL21_PIG]] Component of the large ribosomal subunit.<ref>PMID:24930395</ref> [[http://www.uniprot.org/uniprot/RL11_PIG RL11_PIG]] Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity). [[http://www.uniprot.org/uniprot/RL40_PIG RL40_PIG]] Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). 60S ribosomal protein L40: component of the 60S subunit of the ribosome (By similarity). [[http://www.uniprot.org/uniprot/RL10_PIG RL10_PIG]] Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.[UniProtKB:P27635] [[http://www.uniprot.org/uniprot/RL6_PIG RL6_PIG]] Component of the large ribosomal subunit.<ref>PMID:24930395</ref> [[http://www.uniprot.org/uniprot/A0A480UVT3_PIG A0A480UVT3_PIG]] Binds to the 23S rRNA.[RuleBase:RU000576] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 23: | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
Revision as of 17:28, 6 March 2020
Structure of the idle mammalian ribosome-Sec61 complex
| |||||||||
