3jah

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{{Large structure}}
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==Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon==
==Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon==
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<StructureSection load='3jah' size='340' side='right' caption='[[3jah]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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<SX load='3jah' size='340' side='right' viewer='molstar' caption='[[3jah]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3jah]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JAH FirstGlance]. <br>
<table><tr><td colspan='2'>[[3jah]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JAH FirstGlance]. <br>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jah OCA], [http://pdbe.org/3jah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jah RCSB], [http://www.ebi.ac.uk/pdbsum/3jah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jah ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jah OCA], [http://pdbe.org/3jah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jah RCSB], [http://www.ebi.ac.uk/pdbsum/3jah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jah ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
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==See Also==
==See Also==
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*[[TRNA|TRNA]]
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*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: European rabbit]]
[[Category: European rabbit]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Brown, A]]
[[Category: Brown, A]]

Revision as of 17:34, 6 March 2020

Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon

3jah, resolution 3.45Å

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