5mrc

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{{Large structure}}
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==Structure of the yeast mitochondrial ribosome - Class A==
==Structure of the yeast mitochondrial ribosome - Class A==
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<StructureSection load='5mrc' size='340' side='right' caption='[[5mrc]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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<SX load='5mrc' size='340' side='right' viewer='molstar' caption='[[5mrc]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mrc]] is a 77 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MRC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mrc]] is a 77 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MRC FirstGlance]. <br>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrc OCA], [http://pdbe.org/5mrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mrc RCSB], [http://www.ebi.ac.uk/pdbsum/5mrc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrc OCA], [http://pdbe.org/5mrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mrc RCSB], [http://www.ebi.ac.uk/pdbsum/5mrc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrc ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RT23_YEAST RT23_YEAST]] Required for maintenance of mitochondrial DNA.<ref>PMID:11017876</ref> [[http://www.uniprot.org/uniprot/RTC6_YEAST RTC6_YEAST]] Probable component of the mitochondrial large ribosomal subunit involved in ribosome biogenesis and translation. May be involved in a process influencing telomere capping.<ref>PMID:9392081</ref> <ref>PMID:18845848</ref> <ref>PMID:20691087</ref> [[http://www.uniprot.org/uniprot/HIBCH_YEAST HIBCH_YEAST]] Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit.<ref>PMID:11378903</ref> <ref>PMID:14566057</ref> [[http://www.uniprot.org/uniprot/RT17_YEAST RT17_YEAST]] May have a meiosis-specific role as it accumulates during the middle stage of sporulation.<ref>PMID:15543521</ref> [[http://www.uniprot.org/uniprot/RT24_YEAST RT24_YEAST]] Involved in mitochondrial genome encoded proteins translation. [[http://www.uniprot.org/uniprot/RT10_YEAST RT10_YEAST]] Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity). [[http://www.uniprot.org/uniprot/RT12_YEAST RT12_YEAST]] Required for respiratory growth.<ref>PMID:11780787</ref> [[http://www.uniprot.org/uniprot/RSM28_YEAST RSM28_YEAST]] Involved in mitochondrial genome encoded proteins translation. [[http://www.uniprot.org/uniprot/MRP10_YEAST MRP10_YEAST]] Involved in mitochondrial genome encoded proteins translation.<ref>PMID:9065385</ref> [[http://www.uniprot.org/uniprot/COX24_YEAST COX24_YEAST]] Involved in the splicing of the COX1 mRNA.<ref>PMID:16339141</ref> [[http://www.uniprot.org/uniprot/FYV4_YEAST FYV4_YEAST]] Involved in telomere length regulation and required for survival upon exposure to K1 killer toxin.<ref>PMID:12663529</ref> <ref>PMID:16552446</ref> [[http://www.uniprot.org/uniprot/MHR1_YEAST MHR1_YEAST]] Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells.<ref>PMID:11121487</ref> <ref>PMID:9736700</ref> <ref>PMID:7664749</ref> <ref>PMID:12198175</ref> <ref>PMID:12034822</ref> <ref>PMID:14565971</ref> <ref>PMID:16337661</ref> [[http://www.uniprot.org/uniprot/RM36_YEAST RM36_YEAST]] Involved in mitochondrial translation. Overexpression suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions.<ref>PMID:11259585</ref> <ref>PMID:15166137</ref> [[http://www.uniprot.org/uniprot/IMG1_YEAST IMG1_YEAST]] Essential for respiration.<ref>PMID:8771712</ref> [[http://www.uniprot.org/uniprot/RM06_YEAST RM06_YEAST]] Indispensable for mitochondrial function. [[http://www.uniprot.org/uniprot/RMAR_YEAST RMAR_YEAST]] Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.<ref>PMID:7770043</ref>
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[[http://www.uniprot.org/uniprot/RT23_YEAST RT23_YEAST]] Required for maintenance of mitochondrial DNA.<ref>PMID:11017876</ref> [[http://www.uniprot.org/uniprot/HIBCH_YEAST HIBCH_YEAST]] Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit.<ref>PMID:11378903</ref> <ref>PMID:14566057</ref> [[http://www.uniprot.org/uniprot/RTC6_YEAST RTC6_YEAST]] Probable component of the mitochondrial large ribosomal subunit involved in ribosome biogenesis and translation. May be involved in a process influencing telomere capping.<ref>PMID:9392081</ref> <ref>PMID:18845848</ref> <ref>PMID:20691087</ref> [[http://www.uniprot.org/uniprot/RT17_YEAST RT17_YEAST]] May have a meiosis-specific role as it accumulates during the middle stage of sporulation.<ref>PMID:15543521</ref> [[http://www.uniprot.org/uniprot/RT24_YEAST RT24_YEAST]] Involved in mitochondrial genome encoded proteins translation. [[http://www.uniprot.org/uniprot/RT10_YEAST RT10_YEAST]] Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity). [[http://www.uniprot.org/uniprot/RT12_YEAST RT12_YEAST]] Required for respiratory growth.<ref>PMID:11780787</ref> [[http://www.uniprot.org/uniprot/RSM28_YEAST RSM28_YEAST]] Involved in mitochondrial genome encoded proteins translation. [[http://www.uniprot.org/uniprot/MRP10_YEAST MRP10_YEAST]] Involved in mitochondrial genome encoded proteins translation.<ref>PMID:9065385</ref> [[http://www.uniprot.org/uniprot/COX24_YEAST COX24_YEAST]] Involved in the splicing of the COX1 mRNA.<ref>PMID:16339141</ref> [[http://www.uniprot.org/uniprot/FYV4_YEAST FYV4_YEAST]] Involved in telomere length regulation and required for survival upon exposure to K1 killer toxin.<ref>PMID:12663529</ref> <ref>PMID:16552446</ref> [[http://www.uniprot.org/uniprot/MHR1_YEAST MHR1_YEAST]] Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells.<ref>PMID:11121487</ref> <ref>PMID:9736700</ref> <ref>PMID:7664749</ref> <ref>PMID:12198175</ref> <ref>PMID:12034822</ref> <ref>PMID:14565971</ref> <ref>PMID:16337661</ref> [[http://www.uniprot.org/uniprot/RM36_YEAST RM36_YEAST]] Involved in mitochondrial translation. Overexpression suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions.<ref>PMID:11259585</ref> <ref>PMID:15166137</ref> [[http://www.uniprot.org/uniprot/IMG1_YEAST IMG1_YEAST]] Essential for respiration.<ref>PMID:8771712</ref> [[http://www.uniprot.org/uniprot/RM06_YEAST RM06_YEAST]] Indispensable for mitochondrial function. [[http://www.uniprot.org/uniprot/RMAR_YEAST RMAR_YEAST]] Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.<ref>PMID:7770043</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: 3-hydroxyisobutyryl-CoA hydrolase]]
[[Category: 3-hydroxyisobutyryl-CoA hydrolase]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Amunts, A]]
[[Category: Amunts, A]]

Revision as of 19:10, 6 March 2020

Structure of the yeast mitochondrial ribosome - Class A

5mrc, resolution 3.25Å

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