1aoj

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[[Image:1aoj.gif|left|200px]]
[[Image:1aoj.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1aoj| PDB=1aoj | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoj OCA], [http://www.ebi.ac.uk/pdbsum/1aoj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aoj RCSB]</span>
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'''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER'''
'''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER'''
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[[Category: Kishan, K V.R.]]
[[Category: Kishan, K V.R.]]
[[Category: Newcomer, M E.]]
[[Category: Newcomer, M E.]]
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[[Category: eps8]]
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[[Category: Eps8]]
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[[Category: proline rich peptide]]
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[[Category: Proline rich peptide]]
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[[Category: sh3 domain]]
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[[Category: Sh3 domain]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:31:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:44:27 2008''
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Revision as of 07:31, 2 May 2008

Image:1aoj.gif

Template:STRUCTURE 1aoj

THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER


Overview

SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.

About this Structure

1AOJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002 Page seeded by OCA on Fri May 2 10:31:00 2008

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