6e9z
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==DHF119 filament== | |
| + | <SX load='6e9z' size='340' side='right' viewer='molstar' caption='[[6e9z]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6e9z]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E9Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e9z OCA], [http://pdbe.org/6e9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e9z RCSB], [http://www.ebi.ac.uk/pdbsum/6e9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e9z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We describe a general computational approach to designing self-assembling helical filaments from monomeric proteins and use this approach to design proteins that assemble into micrometer-scale filaments with a wide range of geometries in vivo and in vitro. Cryo-electron microscopy structures of six designs are close to the computational design models. The filament building blocks are idealized repeat proteins, and thus the diameter of the filaments can be systematically tuned by varying the number of repeat units. The assembly and disassembly of the filaments can be controlled by engineered anchor and capping units built from monomers lacking one of the interaction surfaces. The ability to generate dynamic, highly ordered structures that span micrometers from protein monomers opens up possibilities for the fabrication of new multiscale metamaterials. | ||
| - | + | De novo design of self-assembling helical protein filaments.,Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L, Dowling Q, Oberdorfer G, Stewart L, Wordeman L, De Yoreo J, Jacobs-Wagner C, Kollman J, Baker D Science. 2018 Nov 9;362(6415):705-709. doi: 10.1126/science.aau3775. PMID:30409885<ref>PMID:30409885</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6e9z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct sequences]] | ||
| + | [[Category: Baker, D]] | ||
| + | [[Category: Fallas, J A]] | ||
| + | [[Category: Kollman, J M]] | ||
| + | [[Category: Lynch, E M]] | ||
| + | [[Category: Shen, H]] | ||
| + | [[Category: Filament]] | ||
| + | [[Category: Protein design]] | ||
| + | [[Category: Protein fibril]] | ||
Revision as of 21:04, 6 March 2020
DHF119 filament
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