1aq1

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[[Image:1aq1.gif|left|200px]]
[[Image:1aq1.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1aq1 |SIZE=350|CAPTION= <scene name='initialview01'>1aq1</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1aq1", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=STB:Staurosporine+Binding+Site'>STB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1aq1| PDB=1aq1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aq1 OCA], [http://www.ebi.ac.uk/pdbsum/1aq1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aq1 RCSB]</span>
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}}
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'''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE'''
'''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE'''
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[[Category: Noble, M E.M.]]
[[Category: Noble, M E.M.]]
[[Category: Tunnah, P.]]
[[Category: Tunnah, P.]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: inhibition]]
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[[Category: Inhibition]]
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[[Category: mitosis]]
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[[Category: Mitosis]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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[[Category: staurosporine]]
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[[Category: Staurosporine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:34:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:45:15 2008''
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Revision as of 07:34, 2 May 2008

Image:1aq1.gif

Template:STRUCTURE 1aq1

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE


Overview

Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.

About this Structure

1AQ1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743 Page seeded by OCA on Fri May 2 10:34:07 2008

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OCA

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