Transthyretin
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<scene name='46/466524/Cv/3'>The hormone tyrosine is bound in the active site of TTR</scene><ref>PMID:1730601</ref>. | <scene name='46/466524/Cv/3'>The hormone tyrosine is bound in the active site of TTR</scene><ref>PMID:1730601</ref>. | ||
| + | ==3D structures of transthyretin== | ||
| + | [[Transthyretin 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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*Transthyretin | *Transthyretin | ||
| - | **[[2pab]], [[1tta]], [[1ttb]], [[1etb]], [[1bmz]], [[1f41]], [[1dvq]], [[1fh2]], [[1qwh]], [[2h4e]], [[2qgb]], [[3cbr]], [[3d7p]], [[3cfm]], [[3i9p]], [[3a4d]], [[3a4e]], [[3a4f]], [[3u2i]], [[3w3b]], [[4mrb]], [[4pvl]], [[4pvn]], [[5k1j]], [[5k1n]], [[5cn3]], [[5cnh]], [[5dwp]], [[4tlt]], [[5lll]] | + | **[[2pab]], [[1tta]], [[1ttb]], [[1etb]], [[1bmz]], [[1f41]], [[1dvq]], [[1fh2]], [[1qwh]], [[2h4e]], [[2qgb]], [[3cbr]], [[3d7p]], [[3cfm]], [[3i9p]], [[3a4d]], [[3a4e]], [[3a4f]], [[3u2i]], [[3w3b]], [[4mrb]], [[4pvl]], [[4pvn]], [[5k1j]], [[5k1n]], [[5cn3]], [[5cnh]], [[5dwp]], [[4tlt]], [[5lll]], [[5n7c]], [[5n62]], [[5n5q]], [[3ssg]], [[1zcr]], [[1zd6]] – hTTR – human<br /> |
**[[3u2j]], [[4pvm]] – hTTR - neutron<br /> | **[[3u2j]], [[4pvm]] – hTTR - neutron<br /> | ||
| - | **[[1eta]], [[1ttc]], [[1tsh]], [[2trh]], [[2try]], [[1bzd]], [[1bze]], [[1fhn]], [[1g1o]], [[1x7s]], [[2qel]], [[3dgd]], [[3did]], [[3kgs]], [[3tfb]] – hTTR (amyloidogenic mutant) | + | **[[1eta]], [[1ttc]], [[1tsh]], [[2trh]], [[2try]], [[1bzd]], [[1bze]], [[1fhn]], [[1g1o]], [[1x7s]], [[2qel]], [[3dgd]], [[3did]], [[3kgs]], [[3tfb]] – hTTR (amyloidogenic mutant)<br /> |
| - | + | **[[6sdz]] - hTTR (amyloidogenic mutant) – Cryo EM<br /> | |
**[[1ttr]] – hTTR (cardiomyapatic mutant) | **[[1ttr]] – hTTR (cardiomyapatic mutant) | ||
| - | **[[1bz8]], [[5ttr]], [[1f86]], [[1gko]], [[1iii]], [[1iik]], [[1ijn]], [[1sok]], [[1soq]], [[1x7t]], [[2g3x]], [[2g3z]], [[2g4e]], [[2g4g]], [[2noy]], [[3bt0]], [[3cxf]], [[3djr]], [[3djs]], [[3djt]], [[3djz]], [[3dk0]], [[3dk2]], [[3do4]], [[3gps]], [[3grb]], [[3grg]], [[3i9a]], [[3i9i]], [[4mrc]], [[4pwe]], [[5dej]], [[5clx]], [[5clx]], [[5clz]], [[5cm1]], [[4tlu]], [[4tnf]], [[4tng]], [[4tkw]], [[4tl4]], [[4tl5]], [[4tlk]], [[4tls]], [[4tm9]], [[4tne]], [[5llv]], [[5h0z]], [[5h0y]], [[5h0x]], [[5h0w]], [[5h0v]], [[5fw8]], [[5fw7]], [[5fw6]], [[5fo2]], [[5cly]] – hTTR (mutant) | + | **[[1bz8]], [[5ttr]], [[1f86]], [[1gko]], [[1iii]], [[1iik]], [[1ijn]], [[1sok]], [[1soq]], [[1x7t]], [[2g3x]], [[2g3z]], [[2g4e]], [[2g4g]], [[2noy]], [[3bt0]], [[3cxf]], [[3djr]], [[3djs]], [[3djt]], [[3djz]], [[3dk0]], [[3dk2]], [[3do4]], [[3gps]], [[3grb]], [[3grg]], [[3i9a]], [[3i9i]], [[4mrc]], [[4pwe]], [[5dej]], [[5clx]], [[5clx]], [[5clz]], [[5cm1]], [[4tlu]], [[4tnf]], [[4tng]], [[4tkw]], [[4tl4]], [[4tl5]], [[4tlk]], [[4tls]], [[4tm9]], [[4tne]], [[5llv]], [[5h0z]], [[5h0y]], [[5h0x]], [[5h0w]], [[5h0v]], [[5fw8]], [[5fw7]], [[5fw6]], [[5fo2]], [[5cly]], [[6fzl]], [[6fxu]], [[6fwd]], [[6e71]], [[6e75]], [[6e76]], [[5oq0]], [[5nfw]], [[5nfe]] – hTTR (mutant)<br /> |
| - | + | **[[2nbp]], [[2nbo]] – hTTR (mutant) – NMR<br /> | |
| - | **[[ | + | |
| - | + | ||
**[[2qpf]] – TTR - mouse | **[[2qpf]] – TTR - mouse | ||
| - | **[[1oo2]], [[1sn2]] – | + | **[[1gke]] – rTTR – rat<br /> |
| - | + | **[[1tfp]] – TTR – chicken<br /> | |
| - | **[[ | + | **[[1oo2]], [[1sn2]] – sbTTR – sea bream<br /> |
| + | **[[3uaf]] – TTR-52 (mutant) – ''Caenorhabditis elegans''<br /> | ||
*Transthyretin binary complexes | *Transthyretin binary complexes | ||
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**[[1bm7]], [[3ozl]] – hTTR + flufenamic acid | **[[1bm7]], [[3ozl]] – hTTR + flufenamic acid | ||
| - | **[[1dvs]], [[1dvt]], [[1dvu]], [[1dvx]], [[1dvy]], [[1dvz]], [[1tt6]], [[1tz8]], [[2f8i]], [[2fbr]], [[2flm]], [[2g5u]], [[2g9k]], [[2gab]], [[2qgc]], [[2qgd]], [[2qge]], [[3cn0]], [[3cn1]], [[3cn2]], [[3cn3]], [[3cn4]], [[3esn]], [[3eso]], [[3esp]], [[3glz]], [[3gs0]], [[3gs4]], [[3gs7]], [[3imr]], [[3ims]], [[3imt]], [[3imu]], [[3imv]], [[3imw]], [[3ipb]], [[3ipe]], [[3m10]], [[2fbr]], [[2flm]], [[3m1o]], [[3tct]], [[4fi7]], [[4fi8]], [[4fi6]], [[5tzl]] – hTTR + amyloid disease inhibitor<br /> | + | **[[1dvs]], [[1dvt]], [[1dvu]], [[1dvx]], [[1dvy]], [[1dvz]], [[1tt6]], [[1tz8]], [[2f8i]], [[2fbr]], [[2flm]], [[2g5u]], [[2g9k]], [[2gab]], [[2qgc]], [[2qgd]], [[2qge]], [[3cn0]], [[3cn1]], [[3cn2]], [[3cn3]], [[3cn4]], [[3esn]], [[3eso]], [[3esp]], [[3glz]], [[3gs0]], [[3gs4]], [[3gs7]], [[3imr]], [[3ims]], [[3imt]], [[3imu]], [[3imv]], [[3imw]], [[3ipb]], [[3ipe]], [[3m10]], [[2fbr]], [[2flm]], [[3m1o]], [[3tct]], [[4fi7]], [[4fi8]], [[4fi6]], [[5tzl]], [[6e6z]] – hTTR + amyloid disease inhibitor<br /> |
| - | **[[4his]], [[4hiq]] - hTTR (mutant) + amyloid disease inhibitor<br /> | + | **[[4his]], [[4hiq]], [[6imx]], [[6imy]], [[6e72]], [[6e74]], [[6e77]] - hTTR (mutant) + amyloid disease inhibitor<br /> |
| + | **[[6fft]] - hTTR (mutant) + amyloid disease inhibitor - Neutron<br /> | ||
**[[4abq]], [[4abv]], [[4abw]], [[4ac2]], [[4ac4]], [[4act]], [[4ank]], [[4abu]] – hTTR + ligand<br /> | **[[4abq]], [[4abv]], [[4abw]], [[4ac2]], [[4ac4]], [[4act]], [[4ank]], [[4abu]] – hTTR + ligand<br /> | ||
**[[4des]], [[4det]], [[4der]], [[4dew]], [[4deu]] – hTTR + flavonoid<br /> | **[[4des]], [[4det]], [[4der]], [[4dew]], [[4deu]] – hTTR + flavonoid<br /> | ||
| - | **[[1u21]], [[3cfn]], [[3cfq]], [[3cft]], [[3hj0]], [[3nee]], [[3neo]], [[3p3r]], [[3p3s]], [[3p3t]], [[3p3u]], [[4ky2]], [[4mas]], [[5e23]], [[5e4a]], [[5e4o]], [[5ezp]], [[5ayt]], [[4ydm]], [[4ydn]], [[4tq8]], [[4tqh]], [[4tqi]], [[4tqp]], [[5jim]], [[5jid]] | + | **[[1u21]], [[3cfn]], [[3cfq]], [[3cft]], [[3hj0]], [[3nee]], [[3neo]], [[3p3r]], [[3p3s]], [[3p3t]], [[3p3u]], [[4ky2]], [[4mas]], [[5e23]], [[5e4a]], [[5e4o]], [[5ezp]], [[5ayt]], [[4ydm]], [[4ydn]], [[4tq8]], [[4tqh]], [[4tqi]], [[4tqp]], [[5jim]], [[5jid]], [[6gr7]], [[6ep1]], [[5u4g]] – hTTR + inhibitor<br /> |
**[[3nes]], [[3nex]] – hTTR (mutant) + inhibitor<br /> | **[[3nes]], [[3nex]] – hTTR (mutant) + inhibitor<br /> | ||
| - | **[[1e3f]], [[1e4h]], [[1e5a]], [[2b15]], [[5hjg]], [[ | + | **[[1e3f]], [[1e4h]], [[1e5a]], [[2b15]], [[5hjg]], [[5l4j]] – hTTR + phenol derivative<br /> |
**[[4l1s]] - hTTR + benzamide derivative<br /> | **[[4l1s]] - hTTR + benzamide derivative<br /> | ||
**[[4l1t]] - hTTR + benzoate derivative<br /> | **[[4l1t]] - hTTR + benzoate derivative<br /> | ||
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**[[4n85]], [[4n86]] - hTTR + glabridin<br /> | **[[4n85]], [[4n86]] - hTTR + glabridin<br /> | ||
**[[4n87]] - hTTR (mutant) + glabridin<br /> | **[[4n87]] - hTTR (mutant) + glabridin<br /> | ||
| - | **[[2b14]], [[2b16]] – hTTR (mutant) + phenol derivative | + | **[[2b14]], [[2b16]] – hTTR (mutant) + phenol derivative<br /> |
| - | + | **[[6r66]], [[6r67]], [[6r68]] - hTTR + flurbiprofen analog<br /> | |
| + | **[[6r6i]] - hTTR (mutant) + flurbiprofen analog<br /> | ||
**[[3kgt]], [[3kgu]], [[5akv]] – hTTR (mutant) + genistein derivative | **[[3kgt]], [[3kgu]], [[5akv]] – hTTR (mutant) + genistein derivative | ||
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**[[1tyr]] – hTTR + retinoic acid | **[[1tyr]] – hTTR + retinoic acid | ||
| - | |||
| - | **[[1kgi]] – rTTR + tetraiodotyroacetic acid | ||
**[[1z7j]] - hTTR + tetraiodotyroacetic acid | **[[1z7j]] - hTTR + tetraiodotyroacetic acid | ||
| - | + | **[[1y1d]], [[2b77]], [[2b9a]], [[3d2t]], [[3fc8]], [[3fcb]], [[2f7i]], [[4ikl]], [[4ikk]], [[4ikl]], [[4iki]], [[4ik7]], [[4ik6]], [[4iiz]], [[4ikj]], [[5l4i]], [[6e70]], [[6d0w]] – hTTR + NSAID drug<br /> | |
| - | + | **[[4i89]], [[6e78]], [[6e73]] - hTTR (mutant) + NSAID drug<br /> | |
| - | + | ||
| - | + | ||
| - | **[[1y1d]], [[2b77]], [[2b9a]], [[3d2t]], [[3fc8]], [[3fcb]], [[2f7i]], [[4ikl]], [[4ikk]], [[4ikl]], [[4iki]], [[4ik7]], [[4ik6]], [[4iiz]], [[4ikj]] – hTTR + NSAID<br /> | + | |
| - | **[[4i89]] - hTTR (mutant) + NSAID<br /> | + | |
**[[4i87]], [[4i85]] - hTTR (mutant) + fibrillogenesis inhibitor <br /> | **[[4i87]], [[4i85]] - hTTR (mutant) + fibrillogenesis inhibitor <br /> | ||
**[[3b56]] – hTTR + salicylic acid derivative<br /> | **[[3b56]] – hTTR + salicylic acid derivative<br /> | ||
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**[[4wo0]] - hTTR + apigenin<br /> | **[[4wo0]] - hTTR + apigenin<br /> | ||
**[[5boj]] - hTTR + gemfibrozil<br /> | **[[5boj]] - hTTR + gemfibrozil<br /> | ||
| - | **[[6gnm]] - sbTTR + benzophenone derivative | + | **[[1kgi]] – rTTR + tetraiodotyroacetic acid<br /> |
| + | **[[1kgj]] – rTTR + dibromoflavone<br /> | ||
| + | **[[6gnm]] - sbTTR + benzophenone derivative<br /> | ||
**[[6gno]], [[6gnw]] - sbTTR + phenol derivative <br /> | **[[6gno]], [[6gnw]] - sbTTR + phenol derivative <br /> | ||
**[[6gnp]], [[6gnr]] - sbTTR + pyridine derivative <br /> | **[[6gnp]], [[6gnr]] - sbTTR + pyridine derivative <br /> | ||
Revision as of 10:07, 8 March 2020
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3D structures of transthyretin
Updated on 08-March-2020
References
- ↑ Robbins J. Transthyretin from discovery to now. Clin Chem Lab Med. 2002 Dec;40(12):1183-90. PMID:12553418 doi:http://dx.doi.org/10.1515/CCLM.2002.208
- ↑ Saraiva MJ. Transthyretin mutations in health and disease. Hum Mutat. 1995;5(3):191-6. PMID:7599630 doi:http://dx.doi.org/10.1002/humu.1380050302
- ↑ Wojtczak A, Luft J, Cody V. Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin. J Biol Chem. 1992 Jan 5;267(1):353-7. PMID:1730601
