Transthyretin

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</StructureSection>
</StructureSection>
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==3D structures of transthyretin==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Transthyretin
 
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**[[2pab]], [[1tta]], [[1ttb]], [[1etb]], [[1bmz]], [[1f41]], [[1dvq]], [[1fh2]], [[1qwh]], [[2h4e]], [[2qgb]], [[3cbr]], [[3d7p]], [[3cfm]], [[3i9p]], [[3a4d]], [[3a4e]], [[3a4f]], [[3u2i]], [[3w3b]], [[4mrb]], [[4pvl]], [[4pvn]], [[5k1j]], [[5k1n]], [[5cn3]], [[5cnh]], [[5dwp]], [[4tlt]], [[5lll]], [[5n7c]], [[5n62]], [[5n5q]], [[3ssg]], [[1zcr]], [[1zd6]] – hTTR – human<br />
 
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**[[3u2j]], [[4pvm]] – hTTR - neutron<br />
 
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**[[1eta]], [[1ttc]], [[1tsh]], [[2trh]], [[2try]], [[1bzd]], [[1bze]], [[1fhn]], [[1g1o]], [[1x7s]], [[2qel]], [[3dgd]], [[3did]], [[3kgs]], [[3tfb]] – hTTR (amyloidogenic mutant)<br />
 
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**[[6sdz]] - hTTR (amyloidogenic mutant) – Cryo EM<br />
 
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**[[1ttr]] – hTTR (cardiomyapatic mutant)
 
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**[[1bz8]], [[5ttr]], [[1f86]], [[1gko]], [[1iii]], [[1iik]], [[1ijn]], [[1sok]], [[1soq]], [[1x7t]], [[2g3x]], [[2g3z]], [[2g4e]], [[2g4g]], [[2noy]], [[3bt0]], [[3cxf]], [[3djr]], [[3djs]], [[3djt]], [[3djz]], [[3dk0]], [[3dk2]], [[3do4]], [[3gps]], [[3grb]], [[3grg]], [[3i9a]], [[3i9i]], [[4mrc]], [[4pwe]], [[5dej]], [[5clx]], [[5clx]], [[5clz]], [[5cm1]], [[4tlu]], [[4tnf]], [[4tng]], [[4tkw]], [[4tl4]], [[4tl5]], [[4tlk]], [[4tls]], [[4tm9]], [[4tne]], [[5llv]], [[5h0z]], [[5h0y]], [[5h0x]], [[5h0w]], [[5h0v]], [[5fw8]], [[5fw7]], [[5fw6]], [[5fo2]], [[5cly]], [[6fzl]], [[6fxu]], [[6fwd]], [[6e71]], [[6e75]], [[6e76]], [[5oq0]], [[5nfw]], [[5nfe]] – hTTR (mutant)<br />
 
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**[[2nbp]], [[2nbo]] – hTTR (mutant) – NMR<br />
 
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**[[2qpf]] – TTR - mouse
 
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**[[1gke]] – rTTR – rat<br />
 
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**[[1tfp]] – TTR – chicken<br />
 
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**[[1oo2]], [[1sn2]] – sbTTR – sea bream<br />
 
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**[[3uaf]] – TTR-52 (mutant) – ''Caenorhabditis elegans''<br />
 
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*Transthyretin binary complexes
 
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**[[1thc]], [[2h1x]], [[2h6u]] – hTTR + hydroxyaurone derivative<br />
 
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**[[4pm1]] - hTTR + estradiol derivative<br />
 
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**[[1tlm]] – hTTR + milrinone
 
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**[[1bm7]], [[3ozl]] – hTTR + flufenamic acid
 
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**[[1dvs]], [[1dvt]], [[1dvu]], [[1dvx]], [[1dvy]], [[1dvz]], [[1tt6]], [[1tz8]], [[2f8i]], [[2fbr]], [[2flm]], [[2g5u]], [[2g9k]], [[2gab]], [[2qgc]], [[2qgd]], [[2qge]], [[3cn0]], [[3cn1]], [[3cn2]], [[3cn3]], [[3cn4]], [[3esn]], [[3eso]], [[3esp]], [[3glz]], [[3gs0]], [[3gs4]], [[3gs7]], [[3imr]], [[3ims]], [[3imt]], [[3imu]], [[3imv]], [[3imw]], [[3ipb]], [[3ipe]], [[3m10]], [[2fbr]], [[2flm]], [[3m1o]], [[3tct]], [[4fi7]], [[4fi8]], [[4fi6]], [[5tzl]], [[6e6z]] – hTTR + amyloid disease inhibitor<br />
 
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**[[4his]], [[4hiq]], [[6imx]], [[6imy]], [[6e72]], [[6e74]], [[6e77]] - hTTR (mutant) + amyloid disease inhibitor<br />
 
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**[[6fft]] - hTTR (mutant) + amyloid disease inhibitor - Neutron<br />
 
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**[[4abq]], [[4abv]], [[4abw]], [[4ac2]], [[4ac4]], [[4act]], [[4ank]], [[4abu]] – hTTR + ligand<br />
 
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**[[4des]], [[4det]], [[4der]], [[4dew]], [[4deu]] – hTTR + flavonoid<br />
 
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**[[1u21]], [[3cfn]], [[3cfq]], [[3cft]], [[3hj0]], [[3nee]], [[3neo]], [[3p3r]], [[3p3s]], [[3p3t]], [[3p3u]], [[4ky2]], [[4mas]], [[5e23]], [[5e4a]], [[5e4o]], [[5ezp]], [[5ayt]], [[4ydm]], [[4ydn]], [[4tq8]], [[4tqh]], [[4tqi]], [[4tqp]], [[5jim]], [[5jid]], [[6gr7]], [[6ep1]], [[5u4g]] – hTTR + inhibitor<br />
 
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**[[3nes]], [[3nex]] – hTTR (mutant) + inhibitor<br />
 
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**[[1e3f]], [[1e4h]], [[1e5a]], [[2b15]], [[5hjg]], [[5l4j]] – hTTR + phenol derivative<br />
 
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**[[4l1s]] - hTTR + benzamide derivative<br />
 
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**[[4l1t]] - hTTR + benzoate derivative<br />
 
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**[[5jiq]] - hTTR + benzophenone derivative<br />
 
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**[[5l4m]], [[6grp]] - hTTR + pyridine derivative<br />
 
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**[[4n85]], [[4n86]] - hTTR + glabridin<br />
 
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**[[4n87]] - hTTR (mutant) + glabridin<br />
 
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**[[2b14]], [[2b16]] – hTTR (mutant) + phenol derivative<br />
 
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**[[6r66]], [[6r67]], [[6r68]] - hTTR + flurbiprofen analog<br />
 
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**[[6r6i]] - hTTR (mutant) + flurbiprofen analog<br />
 
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**[[3kgt]], [[3kgu]], [[5akv]] – hTTR (mutant) + genistein derivative
 
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**[[3ng5]] – hTTR (mutant) + epigallocatechin gallate
 
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**[[1tyr]] – hTTR + retinoic acid
 
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**[[1z7j]] - hTTR + tetraiodotyroacetic acid
 
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**[[1y1d]], [[2b77]], [[2b9a]], [[3d2t]], [[3fc8]], [[3fcb]], [[2f7i]], [[4ikl]], [[4ikk]], [[4ikl]], [[4iki]], [[4ik7]], [[4ik6]], [[4iiz]], [[4ikj]], [[5l4i]], [[6e70]], [[6d0w]] – hTTR + NSAID drug<br />
 
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**[[4i89]], [[6e78]], [[6e73]] - hTTR (mutant) + NSAID drug<br />
 
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**[[4i87]], [[4i85]] - hTTR (mutant) + fibrillogenesis inhibitor <br />
 
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**[[3b56]] – hTTR + salicylic acid derivative<br />
 
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**[[4hjs]], [[4hjt]], [[4hju]] – hTTR + covalent kinetic stabilizer<br />
 
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**[[4pmf]] - hTTR + curcumin<br />
 
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**[[4qxv]], [[5en3]], [[5ihh]] - hTTR + luteolin<br />
 
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**[[4qya]] - hTTR (mutant) + luteolin<br />
 
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**[[4pwf]] - hTTR (mutant) + ferulic esterase<br />
 
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**[[4pwg]], [[4pwh]], [[4qrf]] - hTTR (mutant) + caffeic esterase<br />
 
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**[[4pwi]] - hTTR (mutant) + rosamariic acid<br />
 
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**[[4pwj]], [[4pwk]] - hTTR (mutant) + propolis<br />
 
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**[[4d7b]] - hTTR + tocalpone<br />
 
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**[[5a6i]] - hTTR (mutant) + tocalpone<br />
 
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**[[5aks]], [[5akt]], [[5al0]]- hTTR + resveratrol<br />
 
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**[[5al8]] - hTTR + daidzein glucuronide<br />
 
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**[[4y9b]], [[4y9c]], [[4y9e]], [[4y9f]], [[4y9g]] - hTTR (mutant) + mangostin<br />
 
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**[[4wnj]] - hTTR + quercetin<br />
 
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**[[5l4f]] - hTTR + cresol derivative<br />
 
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**[[4wns]], [[5u48]], [[5u49]], [[5u4a]], [[5u4b]], [[5u4c]], [[5u4d]], [[5u4e]], [[5u4f]] [[5u4g]] - hTTR + stilbene derivative<br />
 
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**[[4wo0]] - hTTR + apigenin<br />
 
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**[[5boj]] - hTTR + gemfibrozil<br />
 
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**[[1kgi]] – rTTR + tetraiodotyroacetic acid<br />
 
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**[[1kgj]] – rTTR + dibromoflavone<br />
 
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**[[6gnm]] - sbTTR + benzophenone derivative<br />
 
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**[[6gno]], [[6gnw]] - sbTTR + phenol derivative <br />
 
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**[[6gnp]], [[6gnr]] - sbTTR + pyridine derivative <br />
 
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**[[6gon]], [[6goo]] - sbTTR + perfluorooctanoate <br />
 
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*Transthyretin ternary complexes
 
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**[[4pme]] - hTTR + ferulic acid + curcumin<br />
 
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**[[5cr1]]- hTTR + resveratrol + T4<br />
 
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*Transthyretin complexes with retinol-binding protein
 
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**[[1rlb]], [[1qab]] – hTTR + RBP
 
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**[[2wqa]] – hTTR + RBP + oleic acid
 
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**[[3bsz]] – hTTR + RBP + antibody
 
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*Transthyretin complexes with thyroxine
 
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**[[2rox]], [[1ict]] – hTTR + T4
 
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**[[3ozk]] – hTTR (mutant) + T4
 
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**[[1tha]], [[2roy]] – hTTR + T4 derivative
 
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**[[1ie4]] – rTTR + T4
 
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**[[1sn0]] – gsTTR + T4
 
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**[[1sn5]] – gsTTR + T4 derivative
 
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*Transthyretin peptide amyloid forming
 
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**[[6c3f]], [[6c3g]], [[6c3s]], [[6c3t]], [[6c4o]], [[6c88]], [[4xfn]], [[4xfo]] - hTTR <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:08, 8 March 2020

Human transthyretin complex with tyroxine derivative 1tha

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References

  1. Robbins J. Transthyretin from discovery to now. Clin Chem Lab Med. 2002 Dec;40(12):1183-90. PMID:12553418 doi:http://dx.doi.org/10.1515/CCLM.2002.208
  2. Saraiva MJ. Transthyretin mutations in health and disease. Hum Mutat. 1995;5(3):191-6. PMID:7599630 doi:http://dx.doi.org/10.1002/humu.1380050302
  3. Wojtczak A, Luft J, Cody V. Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin. J Biol Chem. 1992 Jan 5;267(1):353-7. PMID:1730601

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Michal Harel, Alexander Berchansky

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