TRNA methyltransferase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
Trm <scene name='55/553109/Cv/4'>active site</scene> is located at the cleft at the subunit interface<ref>PMID:12773376</ref>. Water molecules are shown as red spheres. | Trm <scene name='55/553109/Cv/4'>active site</scene> is located at the cleft at the subunit interface<ref>PMID:12773376</ref>. Water molecules are shown as red spheres. | ||
| + | ==3D structures of tRNA methyltransferase== | ||
| + | [[tRNA methyltransferase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
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*'''tRNA guanine 37 N1 methyltransferase''' | *'''tRNA guanine 37 N1 methyltransferase''' | ||
| - | **[[3knu]] – ApTrm – ''Anaplasma phagocytophilum'' <br /> | + | **[[3knu]], [[6uev]] – ApTrm – ''Anaplasma phagocytophilum'' <br /> |
**[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br /> | **[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br /> | ||
**[[3ief]] – Trm – ''Bartonella henselae'' <br /> | **[[3ief]] – Trm – ''Bartonella henselae'' <br /> | ||
**[[1uaj]] – HiTrm – ''Haemophilus influenzae''<br /> | **[[1uaj]] – HiTrm – ''Haemophilus influenzae''<br /> | ||
**[[3ky7]] – Trm – ''Staphylococcus aureus''<br /> | **[[3ky7]] – Trm – ''Staphylococcus aureus''<br /> | ||
| - | **[[3quv]] – | + | **[[3quv]], [[6nvr]] – MaTrm – ''Mycobacterium abscessus''<br /> |
| - | **[[5hjj]], [[5yac]] – | + | **[[5hjj]], [[5yac]] – PabTrm – ''Pyrococcus abyssi''<br /> |
| + | **[[6jki]] – PaTrm – ''Pseudomonas aeruginosa''<br /> | ||
| + | **[[5zhi]] – MtTrm – ''Mycobacterium tuberculosis''<br /> | ||
*Complexes of tRNA guanine 37 N1 methyltransferase | *Complexes of tRNA guanine 37 N1 methyltransferase | ||
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**[[4gek]], [[4iwn]] – EcTrm + SAM derivative<br /> | **[[4gek]], [[4iwn]] – EcTrm + SAM derivative<br /> | ||
**[[5hr7]] – EcTrm + tRNA-Glu<br /> | **[[5hr7]] – EcTrm + tRNA-Glu<br /> | ||
| - | **[[5hji]], [[5hjm]] – | + | **[[5hji]], [[5hjm]] – PabTrm + adenosine derivative<br /> |
| - | **[[5hjk]] – PaTrm + SAH <br /> | + | **[[5hjk]] – PabTrm + SAH <br /> |
| + | **[[6qo2]], [[6qo3]], [[6qo4]], [[6qo6]], [[6qoa]], [[6qoc]], [[6qod]], [[6qoe]], [[6qof]], [[6qog]], [[6qoh]], [[6qoi]], [[6qoj]], [[6qok]], [[6qol]], [[6qom]], [[6qon]], [[6qoo]], [[6qop]], [[6qoq]], [[6qor]], [[6qos]], [[6qot]], [[6qou]], [[6qov]], [[6qow]], [[6qox]], [[6qqq]], [[6qqr]], [[6qqt]], [[6qqu]], [[6qqv]], [[6qqw]], [[6qqz]], [[6qr0]], [[6qr1]], [[6qr2]], [[6qr3]], [[6qr4]], [[6qr7]], [[6qr9]], [[6qra]], [[6qrc]], [[6qrd]], [[6qre]], [[6qrf]], [[6qrg]] – MaTrm + inhibitor<br /> | ||
| + | **[[6nw6]] – MaTrm + SAM <br /> | ||
| + | **[[6nw7]] – MaTrm + SAH <br /> | ||
| + | **[[6joe]], [[6jof]], [[5zhm]], [[5zhn]], [[6afk]] – PaTrm + inhibitor<br /> | ||
| + | **[[6wyq]] – PaTrm + SAM <br /> | ||
| + | **[[6wyr]] – PaTrm + SFG <br /> | ||
| + | **[[5zhj]] – MtTrm + SAH <br /> | ||
| + | **[[5zhk]], [[5zhl]] – MtTrm + inhibitor<br /> | ||
| + | **[[5wt1]] – PabTrm + tRNA + SAH <br /> | ||
| + | **[[5wt3]] – PabTrm + tRNA + methylthioadenosine<br /> | ||
*'''tRNA guanine 46 N7 methyltransferase''' | *'''tRNA guanine 46 N7 methyltransferase''' | ||
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**[[2vdu]], [[2vdv]] – yTrm <br /> | **[[2vdu]], [[2vdv]] – yTrm <br /> | ||
**[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br /> | **[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br /> | ||
| - | **[[2fca]] – | + | **[[2fca]] – BsTrm – ''Bacillus subtilis'' <br /> |
**[[3dxx]] – EcTrm <br /> | **[[3dxx]] – EcTrm <br /> | ||
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*'''tRNA cytidine 34 O2 methyltransferase''' | *'''tRNA cytidine 34 O2 methyltransferase''' | ||
| + | **[[6jp6]] – yTrm <br /> | ||
**[[3e5y]] – BpTrm – ''Burkholderia pseudomalllei'' <br /> | **[[3e5y]] – BpTrm – ''Burkholderia pseudomalllei'' <br /> | ||
**[[4jak]], [[4kdz]] – EcTrm <br /> | **[[4jak]], [[4kdz]] – EcTrm <br /> | ||
| + | **[[6qkv]] – PaTrm <br /> | ||
| + | **[[6ahw]] – HiTrm <br /> | ||
*Complexes of tRNA cytidine 34 O2 methyltransferase | *Complexes of tRNA cytidine 34 O2 methyltransferase | ||
| + | **[[6jpl]] – yTrm + SAM <br /> | ||
**[[4kgn]] – BpTrm + SAH <br /> | **[[4kgn]] – BpTrm + SAH <br /> | ||
**[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br /> | **[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br /> | ||
**[[1mxi]], [[1im8]] – HiTrm + SAH <br /> | **[[1mxi]], [[1im8]] – HiTrm + SAH <br /> | ||
**[[4jal]] – EcTrm + SAH<br /> | **[[4jal]] – EcTrm + SAH<br /> | ||
| + | |||
| + | Trm to C5 of cytidine 38 | ||
| + | |||
| + | **[[6fdf]] – fyTrm + SAH <br /> | ||
| + | |||
| + | Trm to O2 of cytidine/uridine | ||
| + | |||
| + | **[[5gra]] – Trm – ''Zymomonas mobilis'' <br /> | ||
| + | **[[5gmc]], [[5gmb]] – PaTrm <b /> | ||
| + | **[[5gm8]] – PaTrm + SFG<br /> | ||
*'''tRNA guanine 6 N2 methyltransferase''' | *'''tRNA guanine 6 N2 methyltransferase''' | ||
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**[[5a7y]] – SaTrm + SAH<br /> | **[[5a7y]] – SaTrm + SAH<br /> | ||
**[[4cng]] – SaTrm (mutant) + SAH<br /> | **[[4cng]] – SaTrm (mutant) + SAH<br /> | ||
| + | |||
| + | *Trm to N1 of adenine 22 | ||
| + | |||
| + | **[[6q56]] – BsTrm (mutant)<br /> | ||
| + | **[[6qe6]] – BsTrm + SAH<br /> | ||
*'''tRNA adenine 58 N1 methyltransferase''' | *'''tRNA adenine 58 N1 methyltransferase''' | ||
Revision as of 09:25, 10 March 2020
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3D structures of tRNA methyltransferase
Updated on 10-March-2020
Trm to C5 of cytidine 38
Trm to O2 of cytidine/uridine
References
- ↑ Swinehart WE, Jackman JE. Diversity in mechanism and function of tRNA methyltransferases. RNA Biol. 2015;12(4):398-411. doi: 10.1080/15476286.2015.1008358. PMID:25626150 doi:http://dx.doi.org/10.1080/15476286.2015.1008358
- ↑ Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK. Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition. EMBO J. 2003 Jun 2;22(11):2593-603. PMID:12773376 doi:10.1093/emboj/cdg269
