1aqc

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[[Image:1aqc.gif|left|200px]]
[[Image:1aqc.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1aqc", creates the "Structure Box" on the page.
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{{STRUCTURE_1aqc| PDB=1aqc | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqc OCA], [http://www.ebi.ac.uk/pdbsum/1aqc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aqc RCSB]</span>
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'''X11 PTB DOMAIN-10MER PEPTIDE COMPLEX'''
'''X11 PTB DOMAIN-10MER PEPTIDE COMPLEX'''
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[[Category: Lee, C H.]]
[[Category: Lee, C H.]]
[[Category: Zhang, Z.]]
[[Category: Zhang, Z.]]
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[[Category: complex (peptide binding module/peptide)]]
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[[Category: Peptide binding module]]
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[[Category: peptide binding module]]
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[[Category: Ptb domain]]
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[[Category: ptb domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:34:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:45:27 2008''
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Revision as of 07:34, 2 May 2008

Image:1aqc.gif

Template:STRUCTURE 1aqc

X11 PTB DOMAIN-10MER PEPTIDE COMPLEX


Overview

The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the unphosphorylated peptides, which contain an NPxY motif, resembles that of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight peptide residues make specific contacts with the X11 PTB domain, and they collectively achieve high affinity (KD = 0.32 microM) and specificity. These results suggest that, in contrast to the SH2 domains, the PTB domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.

About this Structure

1AQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain., Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J, EMBO J. 1997 Oct 15;16(20):6141-50. PMID:9321393 Page seeded by OCA on Fri May 2 10:34:56 2008

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