6m17

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m (Protected "6m17" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6m17 is ON HOLD
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==The 2019-nCoV RBD/ACE2-B0AT1 complex==
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<StructureSection load='6m17' size='340' side='right'caption='[[6m17]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Yan, R.H., Zhang, Y.Y., Li, Y.N., Xia, L., Guo, Y.Y., Zhou, Q.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6m17]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M17 FirstGlance]. <br>
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Description: The 2019-nCoV RBD/ACE2-B0AT1 complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Angiotensin-converting_enzyme_2 Angiotensin-converting enzyme 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.23 3.4.17.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m17 OCA], [http://pdbe.org/6m17 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m17 RCSB], [http://www.ebi.ac.uk/pdbsum/6m17 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m17 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/S6A19_HUMAN S6A19_HUMAN]] Hartnup disease;Iminoglycinuria. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for hyperglycinuria. The disease may be caused by mutations affecting the gene represented in this entry. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families.
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== Function ==
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[[http://www.uniprot.org/uniprot/S6A19_HUMAN S6A19_HUMAN]] Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:19185582, PubMed:15286788). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582, PubMed:18424768).<ref>PMID:15286788</ref> <ref>PMID:18424768</ref> <ref>PMID:18484095</ref> <ref>PMID:19185582</ref> <ref>PMID:26240152</ref> [[http://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN]] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Angiotensin-converting enzyme 2]]
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[[Category: Large Structures]]
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[[Category: Guo, Y Y]]
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[[Category: Li, Y N]]
[[Category: Xia, L]]
[[Category: Xia, L]]
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[[Category: Li, Y.N]]
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[[Category: Yan, R H]]
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[[Category: Guo, Y.Y]]
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[[Category: Zhang, Y Y]]
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[[Category: Zhang, Y.Y]]
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[[Category: Yan, R.H]]
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[[Category: Zhou, Q]]
[[Category: Zhou, Q]]
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[[Category: 2019-ncov rbd]]
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[[Category: Ace2-b0at1 complex]]
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[[Category: Membrane protein]]
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[[Category: Membrane protein-viral protein complex]]

Revision as of 07:21, 11 March 2020

The 2019-nCoV RBD/ACE2-B0AT1 complex

PDB ID 6m17

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