6u0k
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==TTBK2 kinase domain in complex with Compound 1== | |
| - | + | <StructureSection load='6u0k' size='340' side='right'caption='[[6u0k]], [[Resolution|resolution]] 1.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6u0k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U0K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTQ:4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE'>DTQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u0k OCA], [http://pdbe.org/6u0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u0k RCSB], [http://www.ebi.ac.uk/pdbsum/6u0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u0k ProSAT]</span></td></tr> |
| - | [[Category: Chodaparambil, J | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TTBK2_HUMAN TTBK2_HUMAN]] Spinocerebellar ataxia type 11. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TTBK2_HUMAN TTBK2_HUMAN]] Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.<ref>PMID:21548880</ref> <ref>PMID:23141541</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Chodaparambil, J V]] | ||
| + | [[Category: Marcotte, D J]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Ttbk2]] | ||
Revision as of 07:28, 11 March 2020
TTBK2 kinase domain in complex with Compound 1
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