This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6y1e
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)== | |
| - | + | <StructureSection load='6y1e' size='340' side='right'caption='[[6y1e]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6y1e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Y1E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=O7Z:2-[[6,7-bis(chloranyl)-2-cyclopentyl-2-methyl-1-oxidanylidene-3~{H}-inden-5-yl]oxy]ethanoic+acid'>O7Z</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gss|2gss]]</td></tr> |
| - | [[Category: Dirr, H | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6y1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y1e OCA], [http://pdbe.org/6y1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y1e RCSB], [http://www.ebi.ac.uk/pdbsum/6y1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y1e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Glutathione transferase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dirr, H W]] | ||
[[Category: Pandian, R]] | [[Category: Pandian, R]] | ||
| + | [[Category: Sayed, Y]] | ||
[[Category: Thangaraj, V]] | [[Category: Thangaraj, V]] | ||
| - | [[Category: Sayed, Y]] | ||
[[Category: Worth, R]] | [[Category: Worth, R]] | ||
| + | [[Category: Chloride ion channel inhibitor]] | ||
| + | [[Category: Clic1]] | ||
| + | [[Category: Ea]] | ||
| + | [[Category: Ethacrynic acid]] | ||
| + | [[Category: Glutathione transferase p1-1]] | ||
| + | [[Category: Iaa-94]] | ||
| + | [[Category: Indanyloxyacetic acid-94]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:34, 11 March 2020
Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)
| |||||||||||
