Trypsin inhibitor
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The <scene name='59/595821/Cv/4'>binding loop of TI forms multiple contacts with trypsin</scene><ref>PMID:10089404</ref>. Water molecules are shown as red spheres. <scene name='59/595821/Cv/5'>Ca coordination site</scene>. | The <scene name='59/595821/Cv/4'>binding loop of TI forms multiple contacts with trypsin</scene><ref>PMID:10089404</ref>. Water molecules are shown as red spheres. <scene name='59/595821/Cv/5'>Ca coordination site</scene>. | ||
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| + | == 3D Structures of trypsin inhibitor == | ||
| + | [[Trypsin inhibitor 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
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*Trypsin inhibitor | *Trypsin inhibitor | ||
| + | **[[1hx2]] – TI – toad - NMR<br /> | ||
**[[1cti]], [[2cti]], [[3cti]], [[1ha9]], [[1hym]], [[1mit]], [[1tin]], [[2it7]], [[2it8]] – sTI - squash - NMR<br /> | **[[1cti]], [[2cti]], [[3cti]], [[1ha9]], [[1hym]], [[1mit]], [[1tin]], [[2it7]], [[2it8]] – sTI - squash - NMR<br /> | ||
**[[1lu0]], [[2v1v]] – sTI (mutant)<br /> | **[[1lu0]], [[2v1v]] – sTI (mutant)<br /> | ||
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**[[1ata]], [[1atb]], [[1atd]], [[1ate]] – asTI – ascaris - NMR<br /> | **[[1ata]], [[1atb]], [[1atd]], [[1ate]] – asTI – ascaris - NMR<br /> | ||
**[[1dwm]] – TI – flax - NMR<br /> | **[[1dwm]] – TI – flax - NMR<br /> | ||
| - | **[[1hx2]] – TI – toad - NMR<br /> | ||
**[[1ib9]], [[2eti]], [[2let]], [[2ljs]], [[2po8]] – cuTI – cucumber - NMR<br /> | **[[1ib9]], [[2eti]], [[2let]], [[2ljs]], [[2po8]] – cuTI – cucumber - NMR<br /> | ||
**[[1w7z]] – cuTI II – cucumber <br /> | **[[1w7z]] – cuTI II – cucumber <br /> | ||
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**[[3iir]], [[3zc8]], [[3zc9]] – TI – ''Murraya koenigii''<br /> | **[[3iir]], [[3zc8]], [[3zc9]] – TI – ''Murraya koenigii''<br /> | ||
**[[4j2k]] – etTI - earpod tree<br /> | **[[4j2k]] – etTI - earpod tree<br /> | ||
| + | **[[6kv2]] – TI – ''Senna obtusifolia''<br /> | ||
*Trypsin inhibitor complex with protease | *Trypsin inhibitor complex with protease | ||
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**[[3p8f]] – sfTI + membrane-type serine protease<br /> | **[[3p8f]] – sfTI + membrane-type serine protease<br /> | ||
**[[4k1e]], [[4kel]] – sfTI (mutant) + kallikrein-4<br /> | **[[4k1e]], [[4kel]] – sfTI (mutant) + kallikrein-4<br /> | ||
| - | **[[4k8y]] – sfTI + kallikrein-4<br /> | + | **[[4k8y]], [[6o21]] – sfTI + kallikrein-4<br /> |
*Kunitz type trypsin inhibitor | *Kunitz type trypsin inhibitor | ||
| + | **[[1shp]] – TI – sea anemone - NMR<br /> | ||
**[[1avu]], [[1ba7]] – sbTI – soybean<br /> | **[[1avu]], [[1ba7]] – sbTI – soybean<br /> | ||
| + | **[[6ntt]] – sbTI + naphthalene derivative <br /> | ||
| + | **[[1avw]], [[1avx]] – sbTI + trypsin <br /> | ||
| + | **[[6o1f]] – sbTI + tryptase + antibody <br /> | ||
**[[1r8n]] – TI – ''Delonix regia''<br /> | **[[1r8n]] – TI – ''Delonix regia''<br /> | ||
**[[1r8o]] – TI – ''Copaifera langsdorffii''<br /> | **[[1r8o]] – TI – ''Copaifera langsdorffii''<br /> | ||
| - | **[[1shp]] – TI – sea anemone - NMR<br /> | ||
**[[4an6]] – taTI - tamarind <br /> | **[[4an6]] – taTI - tamarind <br /> | ||
| - | **[[1avw]], [[1avx]] – sbTI + trypsin <br /> | ||
**[[4an7]] – taTI + trypsin <br /> | **[[4an7]] – taTI + trypsin <br /> | ||
**[[5xoz]] – TI – chickpea<br /> | **[[5xoz]] – TI – chickpea<br /> | ||
**[[5wvx]] – TI – taro<br /> | **[[5wvx]] – TI – taro<br /> | ||
| + | **[[6a5i]] – TI – ''Pseudocrastes persicus'' - NMR<br /> | ||
*Bowman-Birk type trypsin inhibitor | *Bowman-Birk type trypsin inhibitor | ||
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**[[1bbi]], [[2bbi]] – sbTI – NMR<br /> | **[[1bbi]], [[2bbi]] – sbTI – NMR<br /> | ||
**[[1k9b]] – sbTI <br /> | **[[1k9b]] – sbTI <br /> | ||
| + | **[[1d6r]], [[1g9i]] – sbTI + trypsinogen<br /> | ||
**[[1c2a]], [[2fj8]] – baTI – barley<br /> | **[[1c2a]], [[2fj8]] – baTI – barley<br /> | ||
**[[2r33]] – CoTI - cowpea<br /> | **[[2r33]] – CoTI - cowpea<br /> | ||
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**[[2g81]] – CoTI + trypsin <br /> | **[[2g81]] – CoTI + trypsin <br /> | ||
**[[3ru4]] – CoTI + trypsin + chymotrypsinogen<br /> | **[[3ru4]] – CoTI + trypsin + chymotrypsinogen<br /> | ||
| - | **[[1d6r]], [[1g9i]] – sbTI + trypsinogen<br /> | ||
}} | }} | ||
Revision as of 08:34, 11 March 2020
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3D Structures of trypsin inhibitor
Updated on 11-March-2020
References
- ↑ Song HK, Suh SW. Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator. J Mol Biol. 1998 Jan 16;275(2):347-63. PMID:9466914 doi:10.1006/jmbi.1997.1469
- ↑ Liener IE, Goodale RL, Deshmukh A, Satterberg TL, Ward G, DiPietro CM, Bankey PE, Borner JW. Effect of a trypsin inhibitor from soybeans (Bowman-Birk) on the secretory activity of the human pancreas. Gastroenterology. 1988 Feb;94(2):419-27. PMID:2446949
- ↑ Kanai T, Ishiwata T, Kobayashi T, Sato H, Takizawa M, Kawamura Y, Tsujimoto H, Nakatani K, Ishibashi N, Nishiyama M, Hatai Y, Asano Y, Kobayashi T, Takeshita S, Nonoyama S. Ulinastatin, a urinary trypsin inhibitor, for the initial treatment of patients with Kawasaki disease: a retrospective study. Circulation. 2011 Dec 20;124(25):2822-8. doi: 10.1161/CIRCULATIONAHA.111.028423. , Epub 2011 Nov 21. PMID:22104548 doi:http://dx.doi.org/10.1161/CIRCULATIONAHA.111.028423
- ↑ Helland R, Berglund GI, Otlewski J, Apostoluk W, Andersen OA, Willassen NP, Smalas AO. High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes. Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):139-48. Epub 1999, Jan 1. PMID:10089404 doi:10.1107/S090744499801052X
