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5bqi
From Proteopedia
(Difference between revisions)
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==Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain== | ==Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain== | ||
| - | <StructureSection load='5bqi' size='340' side='right' caption='[[5bqi]], [[Resolution|resolution]] 1.88Å' scene=''> | + | <StructureSection load='5bqi' size='340' side='right'caption='[[5bqi]], [[Resolution|resolution]] 1.88Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5bqi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQI FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5bqi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQI FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1KA:(2-HYDROXYETHOXY)ACETALDEHYDE'>1KA</scene>, <scene name='pdbligand=4UL:2-(DIFLUOROMETHYL)-5-{[(2-METHYLPROPANOYL)AMINO]METHYL}-N-{5-METHYL-4-[4-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOL-2-YL}PYRIDINE-3-CARBOXAMIDE'>4UL</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1KA:(2-HYDROXYETHOXY)ACETALDEHYDE'>1KA</scene>, <scene name='pdbligand=4UL:2-(DIFLUOROMETHYL)-5-{[(2-METHYLPROPANOYL)AMINO]METHYL}-N-{5-METHYL-4-[4-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOL-2-YL}PYRIDINE-3-CARBOXAMIDE'>4UL</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTGES, MGST1L1, MPGES1, PGES, PIG12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqi OCA], [http://pdbe.org/5bqi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bqi RCSB], [http://www.ebi.ac.uk/pdbsum/5bqi PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqi OCA], [http://pdbe.org/5bqi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bqi RCSB], [http://www.ebi.ac.uk/pdbsum/5bqi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqi ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5bqi" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5bqi" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Prostaglandin E synthase|Prostaglandin E synthase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Prostaglandin-E synthase]] | [[Category: Prostaglandin-E synthase]] | ||
[[Category: Antonysamy, S]] | [[Category: Antonysamy, S]] | ||
Revision as of 08:54, 11 March 2020
Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain
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