Tryptophan synthase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The <scene name='52/525189/Cv/6'>active site</scene> of TrpS subunit α contains the catalytic residues Glu and Asp<ref>PMID:16120446</ref>. Water molecules are shown as red spheres. | The <scene name='52/525189/Cv/6'>active site</scene> of TrpS subunit α contains the catalytic residues Glu and Asp<ref>PMID:16120446</ref>. Water molecules are shown as red spheres. | ||
| + | ==3D structures of tryptophan synthase== | ||
| + | [[Tryptophan synthase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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*'''Tryptophan synthase α subunit''' | *'''Tryptophan synthase α subunit''' | ||
| + | **[[1rd5]] - TrpS α subunit – corn<br /> | ||
**[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br /> | **[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br /> | ||
**[[3tha]] - TrpS α subunit – ''Campylobacter jejuni''<br /> | **[[3tha]] - TrpS α subunit – ''Campylobacter jejuni''<br /> | ||
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**[[1geq]] - PfTrpS α subunit - ''Pyrococcus furiosus''<br /> | **[[1geq]] - PfTrpS α subunit - ''Pyrococcus furiosus''<br /> | ||
**[[2dzp]], [[2dzs]], [[2dzt]], [[2dzu]], [[2dzv]], [[2dzw]], [[2dzx]], [[2e09]] - PfTrpS α subunit (mutant)<br /> | **[[2dzp]], [[2dzs]], [[2dzt]], [[2dzu]], [[2dzv]], [[2dzw]], [[2dzx]], [[2e09]] - PfTrpS α subunit (mutant)<br /> | ||
| - | **[[1rd5]] - TrpS α subunit – corn<br /> | ||
**[[1ujp]] - TtTrpS α subunit <br /> | **[[1ujp]] - TtTrpS α subunit <br /> | ||
**[[1v7y]], [[1wq5]], [[1xc4]] - EcTrpS α subunit <br /> | **[[1v7y]], [[1wq5]], [[1xc4]] - EcTrpS α subunit <br /> | ||
**[[1xcf]] - EcTrpS α subunit (mutant)<br /> | **[[1xcf]] - EcTrpS α subunit (mutant)<br /> | ||
**[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br /> | **[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br /> | ||
| - | **[[5kmy]], [[5k9x]] - TrpS α subunit – ''Legionella pneumophila''<br /> | + | **[[5kmy]], [[5k9x]], [[6oky]] - TrpS α subunit – ''Legionella pneumophila''<br /> |
| + | **[[5n2p]] - SsTrpS α subunit – ''Sulfolobus solfataricus''<br /> | ||
*Tryptophan synthase α binary complex | *Tryptophan synthase α binary complex | ||
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**[[1v8z]] - PfTrpS β1 subunit <br /> | **[[1v8z]] - PfTrpS β1 subunit <br /> | ||
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br /> | **[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br /> | ||
| - | **[[4qys]] - SsTrpS β2 subunit | + | **[[4qys]], [[6hte]] - SsTrpS β2 subunit<br /> |
*Tryptophan synthase β complex | *Tryptophan synthase β complex | ||
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**[[1wdw]] - PfTrpS α + β subunits <br /> | **[[1wdw]] - PfTrpS α + β subunits <br /> | ||
| + | **[[6hul]] - SsTrpS α + β subunits <br /> | ||
*Tryptophan synthase α+β binary complex | *Tryptophan synthase α+β binary complex | ||
**[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br /> | **[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br /> | ||
| - | **[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br /> | ||
**[[1k7x]], [[2j9z]] - StTrpS α + β (mutant) + PLP<br /> | **[[1k7x]], [[2j9z]] - StTrpS α + β (mutant) + PLP<br /> | ||
| - | **[[ | + | **[[3pr2]], [[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - StTrpS α + β + inhibitor<br /> |
| - | + | ||
**[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br /> | **[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br /> | ||
| + | **[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br /> | ||
| + | **[[1kfe]] - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate<br /> | ||
| + | **[[6o1h]], [[6dzo]], [[6duc]], [[6d0v]], [[6c73]] - StTrpS α + β (mutant) + inhibitor<br /> | ||
**[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br /> | **[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br /> | ||
| - | **[[ | + | **[[2tys]] - StTrpS α (mutant) + β (mutant) + Trp derivative<br /> |
**[[5kzm]] - TrpS α + β + PLP derivative – ''Francisella tularensis''<br /> | **[[5kzm]] - TrpS α + β + PLP derivative – ''Francisella tularensis''<br /> | ||
**[[5kin]] - TrpS α + β + PLP derivative – ''Streptococcus pneumoniae''<br /> | **[[5kin]] - TrpS α + β + PLP derivative – ''Streptococcus pneumoniae''<br /> | ||
Revision as of 09:11, 11 March 2020
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3D structures of tryptophan synthase
Updated on 11-March-2020
References
- ↑ Miles EW. Tryptophan synthase: a multienzyme complex with an intramolecular tunnel. Chem Rec. 2001;1(2):140-51. PMID:11893063
- ↑ Shen H, Yang Y, Wang F, Zhang Y, Ye N, Xu S, Wang H. Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis. Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):379-88. PMID:19430702
- ↑ Kulik V, Hartmann E, Weyand M, Frey M, Gierl A, Niks D, Dunn MF, Schlichting I. On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. J Mol Biol. 2005 Sep 23;352(3):608-20. PMID:16120446 doi:10.1016/j.jmb.2005.07.014
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