Tubulin
From Proteopedia
(Difference between revisions)
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*α-tubulin | *α-tubulin | ||
| - | **[[2bto]] – PdTUBA+thioredoxin 1 – ''Prosthecobacter dejongeii''<br /> | ||
**[[2e4h]] – hTUBA C terminal + restin CAP-Gly domain 2 – human<br /> | **[[2e4h]] – hTUBA C terminal + restin CAP-Gly domain 2 – human<br /> | ||
| + | **[[2bto]] – PdTUBA+thioredoxin 1 – ''Prosthecobacter dejongeii''<br /> | ||
*α-tubulin + β-tubulin | *α-tubulin + β-tubulin | ||
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*α-tubulin + β-tubulin complexes with stathmin-4 | *α-tubulin + β-tubulin complexes with stathmin-4 | ||
| + | **[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]], [[1ffx]] – bTUBA1C+bTUBB2B+stathmin-4<br /> | ||
| + | **[[5lp6]] – bTUBA1B +bTUBB2B +stathmin-4 + protein<br /> | ||
| + | **[[5la6]], [[5m7e]], [[5bmv]], [[5lov]], [[5lxt]], [[5lxj]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5mf4]], [[5ov7]], [[5lxs]], [[5xlt]], [[5o7a]], [[5xlt]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + inhibitor<br /> | ||
| + | **[[5njh]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + triazolopyrimidine<br /> | ||
**[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]], [[3n2g]], [[3n2k]], [[3ryc]], [[3ryf]], [[3ryh]], [[3ryi]], [[4eb6]] – sTUBA+sTUBB+stathmin-4 – sheep<br /> | **[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]], [[3n2g]], [[3n2k]], [[3ryc]], [[3ryf]], [[3ryh]], [[3ryi]], [[4eb6]] – sTUBA+sTUBB+stathmin-4 – sheep<br /> | ||
**[[4f61]] - sTUBA+sTUBB+stathmin-like protein R4<br /> | **[[4f61]] - sTUBA+sTUBB+stathmin-like protein R4<br /> | ||
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**[[4eb6]] - sTUBA+sTUBB+stathmin-4<br /> | **[[4eb6]] - sTUBA+sTUBB+stathmin-4<br /> | ||
**[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br /> | **[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br /> | ||
| - | **[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]], [[1ffx]] – bTUBA1C+bTUBB2B+stathmin-4<br /> | ||
| - | **[[5lp6]] – bTUBA1B +bTUBB2B +stathmin-4 + protein<br /> | ||
| - | **[[5la6]], [[5m7e]], [[5bmv]], [[5lov]], [[5lxt]], [[5lxj]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5mf4]], [[5ov7]], [[5lxs]], [[5xlt]], [[5o7a]], [[5xlt]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + inhibitor<br /> | ||
| - | **[[5njh]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + triazolopyrimidine<br /> | ||
*α-tubulin + β-tubulin complexes with stathmin-4 and tubulin-tyrosine ligase (TTL) | *α-tubulin + β-tubulin complexes with stathmin-4 and tubulin-tyrosine ligase (TTL) | ||
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**[[6i5c]], [[4i55]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative<br /> | **[[6i5c]], [[4i55]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative<br /> | ||
**[[5jh7]], [[5xaf]], [[5xag]], [[5xlz]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative + drug<br /> | **[[5jh7]], [[5xaf]], [[5xag]], [[5xlz]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative + drug<br /> | ||
| - | **[[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[5eyp]] - sTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + drug<br /> | ||
| - | **[[5kx5]] - sTUBA+sTUBB+stathmin-4 + TTL + GDP + GTP + ADP + inhibitor<br /> | ||
**[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + auristatin anti-mitotics<br /> | **[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + auristatin anti-mitotics<br /> | ||
**[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TTL + drug<br /> | **[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TTL + drug<br /> | ||
| + | **[[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[5eyp]] - sTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + drug<br /> | ||
| + | **[[5kx5]] - sTUBA+sTUBB+stathmin-4 + TTL + GDP + GTP + ADP + inhibitor<br /> | ||
**[[5xp3]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative <br /> | **[[5xp3]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative <br /> | ||
**[[4tuy]], [[4o4h]], [[4o4i]], [[4o4j]], [[4o4l]], [[4i50]], [[4i4t]], [[4tv8]], [[4zhq]], [[4zi7]], [[4zol]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + fungicide<br /> | **[[4tuy]], [[4o4h]], [[4o4i]], [[4o4j]], [[4o4l]], [[4i50]], [[4i4t]], [[4tv8]], [[4zhq]], [[4zi7]], [[4zol]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + fungicide<br /> | ||
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*α-tubulin + β-tubulin complex with kinesin | *α-tubulin + β-tubulin complex with kinesin | ||
| - | **[[ | + | **[[2p4n]] - hTUBA+hTUBB+kinesin heavy chain<br /> |
**[[2wbe]] – bTUBA1D+bTUBB2B+kinesin+AMPPNP <br /> | **[[2wbe]] – bTUBA1D+bTUBB2B+kinesin+AMPPNP <br /> | ||
**[[3dco]] - bTUBA+bTUBB+kinesin-like NOD<br /> | **[[3dco]] - bTUBA+bTUBB+kinesin-like NOD<br /> | ||
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**[[4uxt]], [[4uy0]] - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + taxol – Cryo EM<br /> | **[[4uxt]], [[4uy0]] - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + taxol – Cryo EM<br /> | ||
**[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br /> | **[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br /> | ||
| - | **[[ | + | **[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br /> |
| + | **[[5nd3]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP – Cryo EM<br /> | ||
| + | **[[5nd2]], [[5nd4]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP + ADP – Cryo EM<br /> | ||
| + | **[[5nd7]] - bTUBA+bTUBB+kinesin-like KIF20A + AMPPNP – Cryo EM<br /> | ||
| + | **[[6bbn]] - bTUBA+bTUBB+kinesin-like KIF2A + DARPIN + AMPPNP + GDP + GTP<br /> | ||
| + | **[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br /> | ||
| + | **[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] - bTUBA1D+bTUBB2B+kinesin-5 motor domain + AMPPNP – Cryo EM<br /> | ||
**[[2hxf]], [[6b0c]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP - Cryo EM<br /> | **[[2hxf]], [[6b0c]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP - Cryo EM<br /> | ||
**[[3j6h]] - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM <br /> | **[[3j6h]] - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM <br /> | ||
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**[[6boi]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + taxol – Cryo EM<br /> | **[[6boi]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + taxol – Cryo EM<br /> | ||
**[[6b0l]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + AMPPNP + taxol – Cryo EM<br /> | **[[6b0l]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + AMPPNP + taxol – Cryo EM<br /> | ||
| - | **[[ | + | **[[4lnu]] - sTUBA+sTUBB + ankyrin repeat protein + GDP + GTP + kinesin heavy chain <br /> |
| - | + | **[[5o09]] - PdTUBA+TUBB +GDP + GTP + kinesin light chain - Cryo EM <br /> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | **[[5o09]] - | + | |
*α-tubulin + β-tubulin other complexes | *α-tubulin + β-tubulin other complexes | ||
| - | **[[4drx]] - sTUBA+sTUBB + ankyrin repeat protein<br /> | ||
**[[1tvk]] - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography<br /> | **[[1tvk]] - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography<br /> | ||
**[[3iz0]] - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy<br /> | **[[3iz0]] - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy<br /> | ||
**[[3j1t]], [[3j1u]] - bTUBA+bTUBB+ dynein<br /> | **[[3j1t]], [[3j1u]] - bTUBA+bTUBB+ dynein<br /> | ||
| + | **[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br /> | ||
| + | **[[5nqu]], [[5nqt]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP<br /> | ||
| + | **[[5nm5]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP + colchicine<br /> | ||
| + | **[[5m50]], [[5m54]], [[5m5c]] - bTUBA+bTUBB + calmodulin-regulated spectrin-associated protein + GDP + GTP - Cryo EM<br /> | ||
**[[3j6p]] - pTUBA+pTUBB +GTP + GDP + taxol + dynein heavy chain – Cryo EM<br /> | **[[3j6p]] - pTUBA+pTUBB +GTP + GDP + taxol + dynein heavy chain – Cryo EM<br /> | ||
**[[3j6g]] - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM <br /> | **[[3j6g]] - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM <br /> | ||
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**[[6bjc]] - pTUBA+pTUBB + targeting protein for Xklp2 + GTP + GMPCPP – Cryo EM <br /> | **[[6bjc]] - pTUBA+pTUBB + targeting protein for Xklp2 + GTP + GMPCPP – Cryo EM <br /> | ||
**[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br /> | **[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br /> | ||
| - | **[[ | + | **[[4drx]] - sTUBA+sTUBB + ankyrin repeat protein<br /> |
| - | + | ||
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**[[4ffb]], [[4u3j]] - yTUBA+TUBB (mutant) + protein STU2 <br /> | **[[4ffb]], [[4u3j]] - yTUBA+TUBB (mutant) + protein STU2 <br /> | ||
Revision as of 09:28, 11 March 2020
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3D Structures of Tubulin
Updated on 11-March-2020
References
- ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
- ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
- ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
- ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380
