Tubulin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
== Function ==
== Function ==
-
[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes. '''FtsZ''' (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See [[Cell division protein]] and [[Beta tubulin]].
+
[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes. Tubulin filaments are stabilized by taxol and zampanolide. ''FtsZ''' (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See [[Cell division protein]] and [[Beta tubulin]].
== Relevance ==
== Relevance ==
Line 15: Line 15:
== Structural highlights ==
== Structural highlights ==
*<scene name='43/430888/Cv/6'>γ-tubulin interactions with GTP and Mg+2 ion</scene> ([[1z5w]]).
*<scene name='43/430888/Cv/6'>γ-tubulin interactions with GTP and Mg+2 ion</scene> ([[1z5w]]).
 +
== 3D Structures of Tubulin ==
 +
[[Tubulin 3D Structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of Tubulin ==
== 3D Structures of Tubulin ==
Line 28: Line 31:
*α-tubulin + β-tubulin
*α-tubulin + β-tubulin
 +
**[[5n5n]] – hTUBA-1A+hTUB-3 + GTP + G2P – Cryo EM<br />
 +
**[[6e7b]] – hTUBA-1B+hTUB-3 + GTP + G2P – Cryo EM<br />
 +
**[[5ij0]] – hTUBA-1B+hTUB-3 + GTP + GDP – Cryo EM<br />
 +
**[[5ij9]] – hTUBA-1B+hTUB-3 (mutant) + GTP + GDP – Cryo EM<br />
 +
**[5n5n]] – hTUBA-1B+hTUB-5 + GTP + G2P – Cryo EM<br />
 +
**[6e7c]] – hTUBA-1B+hTUB-2B + GTP + G2P – Cryo EM<br />
 +
**[[6i2i]] – hTUBA-1B +hTUB-5 + GTP + G2P + stabilizer – Cryo EM<br />
**[[1jff]] - bTUBA+bTUBB - bovine<br />
**[[1jff]] - bTUBA+bTUBB - bovine<br />
**[[3j6f]] - pTUBA+pTUBB – pig - Cryo EM <br />
**[[3j6f]] - pTUBA+pTUBB – pig - Cryo EM <br />
Line 33: Line 43:
**[[6dpu]] - pTUBA+pTUBB +GMPCPP + GTP – Cryo EM <br />
**[[6dpu]] - pTUBA+pTUBB +GMPCPP + GTP – Cryo EM <br />
**[[3j7i]] - pTUBA+pTUBB + GTP – Cryo EM<br />
**[[3j7i]] - pTUBA+pTUBB + GTP – Cryo EM<br />
 +
**[[6o2r]], [[6o2q]], [[5xxw]], [[5xxv]], [[5xxt]] - pTUBA+pTUBB +GTP + GDP – Cryo EM<br />
 +
**[[5xxx]] - pTUBA+pTUBB +GTP + G2P – Cryo EM<br />
**[[6evx]], [[6evy]], [[6evz]], [[6ew0]], [[6dpv]], [[6dpw]] - pTUBA+pTUBB + GTP + GDP - Cryo EM<br />
**[[6evx]], [[6evy]], [[6evz]], [[6ew0]], [[6dpv]], [[6dpw]] - pTUBA+pTUBB + GTP + GDP - Cryo EM<br />
**[[1tub]] - pTUBA+pTUBB – electron diffraction<br />
**[[1tub]] - pTUBA+pTUBB – electron diffraction<br />
 +
**[[5w3h]] - yTUBA+ yTUBB +GTP + GDP – yeast - Cryo EM<br />
**[[2btq]] – PdTUBA+PdTUBB<br />
**[[2btq]] – PdTUBA+PdTUBB<br />
**[[5w3f]] - yTUBA+yTUBB + GDP + GTP - yeast<br />
**[[5w3f]] - yTUBA+yTUBB + GDP + GTP - yeast<br />
-
**[[5w3j]] - yTUBA+yTUBB (mutant) + GDP + GTP + taxol<br />
+
**[[5w3j]] - yTUBA+yTUBB (mutant) + GDP + GTP + stabilizer<br />
**[[5ubq]], [[5ucy]] - TUBA+ TUBB – ''Tetrahymena thermophila'' - Cryo EM <br />
**[[5ubq]], [[5ucy]] - TUBA+ TUBB – ''Tetrahymena thermophila'' - Cryo EM <br />
 +
**[[6e88]] - TUBA+ TUBB +GTP + GDP – ''Caenorhabditis elegans'' - Cryo EM<br />
*α-tubulin + β-tubulin complexes with stathmin-4
*α-tubulin + β-tubulin complexes with stathmin-4
Line 51: Line 65:
**[[4eb6]] - sTUBA+sTUBB+stathmin-4<br />
**[[4eb6]] - sTUBA+sTUBB+stathmin-4<br />
**[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br />
**[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br />
 +
**[[6h9b]] - sTUBA+sTUBB+stathmin-4 + GDP + GTP + quinoline derivative<br />
*α-tubulin + β-tubulin complexes with stathmin-4 and tubulin-tyrosine ligase (TTL)
*α-tubulin + β-tubulin complexes with stathmin-4 and tubulin-tyrosine ligase (TTL)
Line 57: Line 72:
**[[4o2a]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ADP + drug<br />
**[[4o2a]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ADP + drug<br />
**[[4ihj]] - bTUBA+bTUBB+stathmin-4 + TTL + ADP<br />
**[[4ihj]] - bTUBA+bTUBB+stathmin-4 + TTL + ADP<br />
-
**[[6i5c]], [[4i55]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative<br />
+
**[[6i5c]], [[4i55]], [[6s9e]], [[6gze]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative<br />
-
**[[5jh7]], [[5xaf]], [[5xag]], [[5xlz]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative + drug<br />
+
**[[6qqn]], [[6knz]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + pyrimidine derivative<br />
 +
**[[6hx8]], [[6gj4]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + quinoline derivative<br />
 +
**[[6k9v]], [[6jcj]], [[6fkl]], [[6fkj]], [[6f7c]], [[5z4p]], [[5yz3]], [[5nfz]], [[5lyj]] – bTUBA + bTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor<br />
 +
**[[5ng1]] – bTUBA + bTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor + stabilizer<br />
 +
**[[6fjf]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + fcmaytansine<br />
 +
**[[6fii]], [[6fjm]], [[6gf3]], [[6qtn]], [[5jh7]], [[5bmv]], [[5la6]], [[5osk]], [[5jvd]], [[5gon]] – bTUBA + bTUBB +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + anti-tumor agent<br />
**[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + auristatin anti-mitotics<br />
**[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + auristatin anti-mitotics<br />
**[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TTL + drug<br />
**[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TTL + drug<br />
Line 68: Line 88:
**[[5xiw]], [[5xke]], [[5xkf]], [[5xkg]], [[5xkh]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + drug<br />
**[[5xiw]], [[5xke]], [[5xkf]], [[5xkg]], [[5xkh]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + drug<br />
**[[5yl4]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + drug<br />
**[[5yl4]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + drug<br />
 +
**[[6o5n]] - pTUBA+pTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + imidazole derivative<br />
 +
**[[5jqg]] - pTUBA+pTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative<br />
 +
**[[6o61]], [[6o5m]] - pTUBA+pTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + imidazole derivative<br />
 +
**[[6nng]], [[6eg5]] - pTUBA+ pTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + pyrimidine derivative<br />
 +
**[[6n47]] - pTUBA+ pTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + pyrimidine derivative<br />
 +
**[[5jcb]], [[5ca0]] - pTUBA+ pTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + depolymerizer<br />
 +
**[[5cb4]] – pTUBA + pTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor<br />
 +
**[[5c8y]] – pTUBA + pTUBB +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + anti-tumor agent<br />
 +
**[[5ezy]] - pTUBA+ bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + stabilizer<br />
 +
**[[5zxh]] - pTUBA+ bTUBB (mutant) +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + imidazole derivative<br />
 +
**[[5z4u]], [[6agk]], [[5h7o]], [[5h74]] – pTUBA + bTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor<br />
 +
**[[5fnv]] – cTUBA + rTUBB +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + anti-tumor agent - chicken<br />
 +
**[[5ca1]] – pTUBA + cTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor<br />
*α-tubulin + β-tubulin complex with kinesin
*α-tubulin + β-tubulin complex with kinesin
Line 76: Line 109:
**[[4ck5]], [[4ck6]], [[4ck7]] - bTUBA+bTUBB+kinesin-like KIF11 motor domain<br />
**[[4ck5]], [[4ck6]], [[4ck7]] - bTUBA+bTUBB+kinesin-like KIF11 motor domain<br />
**[[5mio]] - bTUBA+bTUBB+kinesin-like KIF2C motor domain<br />
**[[5mio]] - bTUBA+bTUBB+kinesin-like KIF2C motor domain<br />
-
**[[5hnw]], [[5hnx]], [[5hny]], [[5hnz]] – bTUBAB1 +bTUBBB2 +kinesin-14 + GDP + GTP + taxol<br />
+
**[[5hnw]], [[5hnx]], [[5hny]], [[5hnz]] – bTUBAB1 +bTUBBB2 +kinesin-14 + GDP + GTP + stabilizer<br />
**[[3edl]] - bTUBA1D+bTUBB2B+kinesin motor domain<br />
**[[3edl]] - bTUBA1D+bTUBB2B+kinesin motor domain<br />
**[[4hna]] - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein<br />
**[[4hna]] - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein<br />
-
**[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxy]] - bTUBA+bTUBB + kinesin motor domain + GDP + GTP + taxol – Cryo EM<br />
+
**[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxy]] - bTUBA+bTUBB + kinesin motor domain + GDP + GTP + stabilizer – Cryo EM<br />
-
**[[4uxt]], [[4uy0]] - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + taxol – Cryo EM<br />
+
**[[4uxt]], [[4uy0]] - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + stabilizer – Cryo EM<br />
**[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br />
**[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br />
**[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br />
**[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br />
Line 88: Line 121:
**[[6bbn]] - bTUBA+bTUBB+kinesin-like KIF2A + DARPIN + AMPPNP + GDP + GTP<br />
**[[6bbn]] - bTUBA+bTUBB+kinesin-like KIF2A + DARPIN + AMPPNP + GDP + GTP<br />
**[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br />
**[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br />
 +
**[[5mm7]] - bTUBA1A+bTUBB +kinesin-4 motor domain + GTP + GDP + ANP + stabilizer – Cryo EM<br />
 +
**[[5mm4]] - bTUBA1A+bTUBB +kinesin-5 motor domain + GTP + GDP + ANP + stabilizer – Cryo EM<br />
 +
**[[5ogc]], [[5oam]] - bTUBA+pTUBB+kinesin-like KIF18A + GTP + GDP + stabilizer – Cryo EM<br />
 +
**[[5ocu]] - bTUBA+pTUBB+kinesin-like KIF18A + GTP + GDP + ANP + stabilizer – Cryo EM<br />
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] - bTUBA1D+bTUBB2B+kinesin-5 motor domain + AMPPNP – Cryo EM<br />
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] - bTUBA1D+bTUBB2B+kinesin-5 motor domain + AMPPNP – Cryo EM<br />
**[[2hxf]], [[6b0c]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP - Cryo EM<br />
**[[2hxf]], [[6b0c]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP - Cryo EM<br />
Line 95: Line 132:
**[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br />
**[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br />
**[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br />
**[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br />
-
**[[6boi]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + taxol – Cryo EM<br />
+
**[[6tiw]] - pTUBA+pTUBB+kinesin-like KIF11 + G2P + quinoline derivative – Cryo EM<br />
-
**[[6b0l]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + AMPPNP + taxol – Cryo EM<br />
+
**[[6ta4]] - pTUBA+pTUBB+kinesin-like KIF11 + GTP + G2P + ANP – Cryo EM<br />
 +
**[[6b0i]] - pTUBA+pTUBB+kinesin-like KLP10A + GTP + GDP + stabilizer – Cryo EM<br />
 +
**[[6vpp]] - pTUBA+pTUBB+kinesin-like KLP61F + GTP + GDP – Cryo EM<br />
 +
**[[6vpo]] - pTUBA+pTUBB+kinesin-like KLP61F + GTP + GDP + ANP – Cryo EM<br />
 +
**[[6mlr]] - pTUBA+pTUBB+kinesin-like KIF7 + GTP + GDP + ANP + stabilizer – Cryo EM<br />
 +
**[[6mlq]] - pTUBA+pTUBB+kinesin-like KIF7 + GTP + GDP + ADP + stabilizer – Cryo EM<br />
 +
**[[6s8m]] - pTUBA+pTUBB+kinesin-like CUT7 + GTP + GDP + ANP – Cryo EM<br />
 +
**[[6boi]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + stabilizer – Cryo EM<br />
 +
**[[6b0l]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + AMPPNP + stabilizer – Cryo EM<br />
**[[4lnu]] - sTUBA+sTUBB + ankyrin repeat protein + GDP + GTP + kinesin heavy chain <br />
**[[4lnu]] - sTUBA+sTUBB + ankyrin repeat protein + GDP + GTP + kinesin heavy chain <br />
 +
**[[5mlv]] - fyTUBA+ fyTUBB+kinesin-like CUT7 + GTP + GDP + ANP – fission yeast - Cryo EM<br />
 +
**[[6u0h]] - TtTUBA+TUBB + GTP + GDP – ''Tetrahymena thermophila'' - Cryo EM<br />
 +
**[[6u0u]], [[6u0t]] - TtTUBA+TUBB+ profilament ribbon protein + GTP + GDP - Cryo EM<br />
**[[5o09]] - PdTUBA+TUBB +GDP + GTP + kinesin light chain - Cryo EM <br />
**[[5o09]] - PdTUBA+TUBB +GDP + GTP + kinesin light chain - Cryo EM <br />
*α-tubulin + β-tubulin other complexes
*α-tubulin + β-tubulin other complexes
 +
**[[6s8l]], [[6s8k]] - hTUBA+hTUBB + ankyrin repeat protein + GDP + GTP + plinabulin<br />
 +
**[[6rza]] - hTUBA+hTUBB +GTP + GDP + stabilizer + dynein heavy chain – Cryo EM<br />
 +
**[[6qvj]], [[6qus]] - hTUBA+hTUBB +GTP + GDP + stabilizer + CAMSAP1 – Cryo EM<br />
 +
**[[6qve]] - hTUBA+hTUBB + GTP + GDP + stabilizer + protein – Cryo EM<br />
 +
**[[6quy]] - hTUBA+hTUBB +GTP + GDP + stabilizer + CKK – Cryo EM<br />
**[[1tvk]] - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography<br />
**[[1tvk]] - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography<br />
**[[3iz0]] - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy<br />
**[[3iz0]] - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy<br />
**[[3j1t]], [[3j1u]] - bTUBA+bTUBB+ dynein<br />
**[[3j1t]], [[3j1u]] - bTUBA+bTUBB+ dynein<br />
**[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br />
**[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br />
 +
**[[5itz]] - bTUBA+bTUBB + CENP-J + darpin + GTP + GDP + colchicine <br />
 +
**[[5eib]] - bTUBA+bTUBB + CENP-J peptide + darpin + GTP + GDP<br />
 +
**[[6kiq]], [[6kio]] - pTUBA+pTUBB + dynein heavy chain – Cryo EM<br />
**[[5nqu]], [[5nqt]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP<br />
**[[5nqu]], [[5nqt]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP<br />
**[[5nm5]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP + colchicine<br />
**[[5nm5]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP + colchicine<br />
**[[5m50]], [[5m54]], [[5m5c]] - bTUBA+bTUBB + calmodulin-regulated spectrin-associated protein + GDP + GTP - Cryo EM<br />
**[[5m50]], [[5m54]], [[5m5c]] - bTUBA+bTUBB + calmodulin-regulated spectrin-associated protein + GDP + GTP - Cryo EM<br />
-
**[[3j6p]] - pTUBA+pTUBB +GTP + GDP + taxol + dynein heavy chain – Cryo EM<br />
+
**[[3j6p]], [[6rzb]] - pTUBA+pTUBB +GTP + GDP + stabilizer + dynein heavy chain – Cryo EM<br />
**[[3j6g]] - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM <br />
**[[3j6g]] - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM <br />
**[[6cvj]], [[6cvn]] - pTUBA+pTUBB + GTP + GDP + tau protein – Cryo EM <br />
**[[6cvj]], [[6cvn]] - pTUBA+pTUBB + GTP + GDP + tau protein – Cryo EM <br />
**[[5kmg]] - pTUBA+pTUBB + protein regulator + GTP + GDP – Cryo EM <br />
**[[5kmg]] - pTUBA+pTUBB + protein regulator + GTP + GDP – Cryo EM <br />
 +
**[[6mzg]], [[6mzf]], [[6mze]] - pTUBA+pTUBB + STU2P + darpin + GTP + GDP <br />
 +
**[[5syg]], [[5syf]], [[5sye]], [[5syc]] - pTUBA+pTUBB + STU2P + stabilizer + GTP + GDP <br />
 +
**[[6gx7]] - sTUBA+sTUBB + alpharep + low calcium response + GTP<br />
 +
**[[6gwd]], [[6gwc]] - sTUBA+sTUBB + alpharep + GTP + GDP<br />
**[[6bjc]] - pTUBA+pTUBB + targeting protein for Xklp2 + GTP + GMPCPP – Cryo EM <br />
**[[6bjc]] - pTUBA+pTUBB + targeting protein for Xklp2 + GTP + GMPCPP – Cryo EM <br />
**[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br />
**[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br />
**[[4drx]] - sTUBA+sTUBB + ankyrin repeat protein<br />
**[[4drx]] - sTUBA+sTUBB + ankyrin repeat protein<br />
**[[4ffb]], [[4u3j]] - yTUBA+TUBB (mutant) + protein STU2 <br />
**[[4ffb]], [[4u3j]] - yTUBA+TUBB (mutant) + protein STU2 <br />
 +
**[[5mjs]] - fyTUBA+ fyTUBB + MAL3 + GTP + GDP + ANP - Cryo EM<br />
*γ-tubulin
*γ-tubulin
 +
**[[6v5v]] – hTUBG1 – Cryo EM<br />
**[[3cb2]] – hTUBG1+GDP<br />
**[[3cb2]] – hTUBG1+GDP<br />
**[[1z5v]] - hTUBG1+GTPgS<br />
**[[1z5v]] - hTUBG1+GTPgS<br />
**[[1z5w]] - hTUBG1+GTP<br />
**[[1z5w]] - hTUBG1+GTP<br />
 +
**[[6v6b]] – hTUBG2 + TUBG3 – Cryo EM<br />
**[[3rip]] – hTUBG4<br />
**[[3rip]] – hTUBG4<br />
 +
**[[6v69]] – hTUBG4 + TUBG5 – Cryo EM<br />
 +
**[[6v6c]] – hTUBG6 – Cryo EM<br />
}}
}}

Revision as of 12:02, 12 March 2020

γ-tubulin complex with GTP and Mg+2 ion (green), 1z5w

Drag the structure with the mouse to rotate

3D Structures of Tubulin

Updated on 12-March-2020

References

  1. ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
  2. ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
  3. ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
  4. ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Tubulin"
Personal tools