Tubulin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 19: Line 19:
</StructureSection>
</StructureSection>
-
== 3D Structures of Tubulin ==
 
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
-
{{#tree:id=OrganizedByTopic|openlevels=0|
 
- 
-
*α-tubulin
 
- 
-
**[[2e4h]] – hTUBA C terminal + restin CAP-Gly domain 2 – human<br />
 
-
**[[2bto]] – PdTUBA+thioredoxin 1 – ''Prosthecobacter dejongeii''<br />
 
- 
-
*α-tubulin + β-tubulin
 
- 
-
**[[5n5n]] – hTUBA-1A+hTUB-3 + GTP + G2P – Cryo EM<br />
 
-
**[[6e7b]] – hTUBA-1B+hTUB-3 + GTP + G2P – Cryo EM<br />
 
-
**[[5ij0]] – hTUBA-1B+hTUB-3 + GTP + GDP – Cryo EM<br />
 
-
**[[5ij9]] – hTUBA-1B+hTUB-3 (mutant) + GTP + GDP – Cryo EM<br />
 
-
**[5n5n]] – hTUBA-1B+hTUB-5 + GTP + G2P – Cryo EM<br />
 
-
**[6e7c]] – hTUBA-1B+hTUB-2B + GTP + G2P – Cryo EM<br />
 
-
**[[6i2i]] – hTUBA-1B +hTUB-5 + GTP + G2P + stabilizer – Cryo EM<br />
 
-
**[[1jff]] - bTUBA+bTUBB - bovine<br />
 
-
**[[3j6f]] - pTUBA+pTUBB – pig - Cryo EM <br />
 
-
**[[3j6e]], [[6evw]] - pTUBA+pTUBB +GMPCPP – Cryo EM <br />
 
-
**[[6dpu]] - pTUBA+pTUBB +GMPCPP + GTP – Cryo EM <br />
 
-
**[[3j7i]] - pTUBA+pTUBB + GTP – Cryo EM<br />
 
-
**[[6o2r]], [[6o2q]], [[5xxw]], [[5xxv]], [[5xxt]] - pTUBA+pTUBB +GTP + GDP – Cryo EM<br />
 
-
**[[5xxx]] - pTUBA+pTUBB +GTP + G2P – Cryo EM<br />
 
-
**[[6evx]], [[6evy]], [[6evz]], [[6ew0]], [[6dpv]], [[6dpw]] - pTUBA+pTUBB + GTP + GDP - Cryo EM<br />
 
-
**[[1tub]] - pTUBA+pTUBB – electron diffraction<br />
 
-
**[[5w3h]] - yTUBA+ yTUBB +GTP + GDP – yeast - Cryo EM<br />
 
-
**[[2btq]] – PdTUBA+PdTUBB<br />
 
-
**[[5w3f]] - yTUBA+yTUBB + GDP + GTP - yeast<br />
 
-
**[[5w3j]] - yTUBA+yTUBB (mutant) + GDP + GTP + stabilizer<br />
 
-
**[[5ubq]], [[5ucy]] - TUBA+ TUBB – ''Tetrahymena thermophila'' - Cryo EM <br />
 
-
**[[6e88]] - TUBA+ TUBB +GTP + GDP – ''Caenorhabditis elegans'' - Cryo EM<br />
 
- 
-
*α-tubulin + β-tubulin complexes with stathmin-4
 
- 
-
**[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]], [[1ffx]] – bTUBA1C+bTUBB2B+stathmin-4<br />
 
-
**[[5lp6]] – bTUBA1B +bTUBB2B +stathmin-4 + protein<br />
 
-
**[[5la6]], [[5m7e]], [[5bmv]], [[5lov]], [[5lxt]], [[5lxj]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5mf4]], [[5ov7]], [[5lxs]], [[5xlt]], [[5o7a]], [[5xlt]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + inhibitor<br />
 
-
**[[5njh]] - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + triazolopyrimidine<br />
 
-
**[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]], [[3n2g]], [[3n2k]], [[3ryc]], [[3ryf]], [[3ryh]], [[3ryi]], [[4eb6]] – sTUBA+sTUBB+stathmin-4 – sheep<br />
 
-
**[[4f61]] - sTUBA+sTUBB+stathmin-like protein R4<br />
 
-
**[[3ut5]] - sTUBA+sTUBB+stathmin-4 + vinca peptide<br />
 
-
**[[4eb6]] - sTUBA+sTUBB+stathmin-4<br />
 
-
**[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br />
 
-
**[[6h9b]] - sTUBA+sTUBB+stathmin-4 + GDP + GTP + quinoline derivative<br />
 
- 
-
*α-tubulin + β-tubulin complexes with stathmin-4 and tubulin-tyrosine ligase (TTL)
 
- 
-
**[[4iij]] - bTUBA+bTUBB+stathmin-4 + TTL<br />
 
-
**[[4o2a]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ADP + drug<br />
 
-
**[[4ihj]] - bTUBA+bTUBB+stathmin-4 + TTL + ADP<br />
 
-
**[[6i5c]], [[4i55]], [[6s9e]], [[6gze]] - bTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + ATP derivative<br />
 
-
**[[6qqn]], [[6knz]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + pyrimidine derivative<br />
 
-
**[[6hx8]], [[6gj4]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + quinoline derivative<br />
 
-
**[[6k9v]], [[6jcj]], [[6fkl]], [[6fkj]], [[6f7c]], [[5z4p]], [[5yz3]], [[5nfz]], [[5lyj]] – bTUBA + bTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor<br />
 
-
**[[5ng1]] – bTUBA + bTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor + stabilizer<br />
 
-
**[[6fjf]] - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + fcmaytansine<br />
 
-
**[[6fii]], [[6fjm]], [[6gf3]], [[6qtn]], [[5jh7]], [[5bmv]], [[5la6]], [[5osk]], [[5jvd]], [[5gon]] – bTUBA + bTUBB +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + anti-tumor agent<br />
 
-
**[[5iyz]], [[5j2t]], [[5j2u]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]] – bTUBAB1 +bTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + auristatin anti-mitotics<br />
 
-
**[[4o2b]] - bTUBA+bTUBB+stathmin-4 + TTL + drug<br />
 
-
**[[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[5eyp]] - sTUBA+bTUBB+stathmin-4 + TTL + GDP + GTP + drug<br />
 
-
**[[5kx5]] - sTUBA+sTUBB+stathmin-4 + TTL + GDP + GTP + ADP + inhibitor<br />
 
-
**[[5xp3]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative <br />
 
-
**[[4tuy]], [[4o4h]], [[4o4i]], [[4o4j]], [[4o4l]], [[4i50]], [[4i4t]], [[4tv8]], [[4zhq]], [[4zi7]], [[4zol]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + fungicide<br />
 
-
**[[6d88]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[5yl2]], [[5ylj]], [[5yls]], [[5xhc]], [[5xi5]], [[5xi7]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + inhibitor<br />
 
-
**[[5xiw]], [[5xke]], [[5xkf]], [[5xkg]], [[5xkh]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + drug<br />
 
-
**[[5yl4]] – pTUBAB1 +pTUBBB2 +stathmin-4 + TTL + GDP + GTP + ATP derivative + drug<br />
 
-
**[[6o5n]] - pTUBA+pTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + imidazole derivative<br />
 
-
**[[5jqg]] - pTUBA+pTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative<br />
 
-
**[[6o61]], [[6o5m]] - pTUBA+pTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + imidazole derivative<br />
 
-
**[[6nng]], [[6eg5]] - pTUBA+ pTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + pyrimidine derivative<br />
 
-
**[[6n47]] - pTUBA+ pTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + pyrimidine derivative<br />
 
-
**[[5jcb]], [[5ca0]] - pTUBA+ pTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + depolymerizer<br />
 
-
**[[5cb4]] – pTUBA + pTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor<br />
 
-
**[[5c8y]] – pTUBA + pTUBB +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + anti-tumor agent<br />
 
-
**[[5ezy]] - pTUBA+ bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + stabilizer<br />
 
-
**[[5zxh]] - pTUBA+ bTUBB (mutant) +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + imidazole derivative<br />
 
-
**[[5z4u]], [[6agk]], [[5h7o]], [[5h74]] – pTUBA + bTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor<br />
 
-
**[[5fnv]] – cTUBA + rTUBB +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + anti-tumor agent - chicken<br />
 
-
**[[5ca1]] – pTUBA + cTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + inhibitor<br />
 
- 
-
*α-tubulin + β-tubulin complex with kinesin
 
- 
-
**[[2p4n]] - hTUBA+hTUBB+kinesin heavy chain<br />
 
-
**[[2wbe]] – bTUBA1D+bTUBB2B+kinesin+AMPPNP <br />
 
-
**[[3dco]] - bTUBA+bTUBB+kinesin-like NOD<br />
 
-
**[[4ck5]], [[4ck6]], [[4ck7]] - bTUBA+bTUBB+kinesin-like KIF11 motor domain<br />
 
-
**[[5mio]] - bTUBA+bTUBB+kinesin-like KIF2C motor domain<br />
 
-
**[[5hnw]], [[5hnx]], [[5hny]], [[5hnz]] – bTUBAB1 +bTUBBB2 +kinesin-14 + GDP + GTP + stabilizer<br />
 
-
**[[3edl]] - bTUBA1D+bTUBB2B+kinesin motor domain<br />
 
-
**[[4hna]] - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein<br />
 
-
**[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxy]] - bTUBA+bTUBB + kinesin motor domain + GDP + GTP + stabilizer – Cryo EM<br />
 
-
**[[4uxt]], [[4uy0]] - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + stabilizer – Cryo EM<br />
 
-
**[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br />
 
-
**[[4aqv]], [[4aqw ]]- bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br />
 
-
**[[5nd3]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP – Cryo EM<br />
 
-
**[[5nd2]], [[5nd4]] - bTUBA+bTUBB+kinesin-like KIF20A + GDP + GTP + ADP – Cryo EM<br />
 
-
**[[5nd7]] - bTUBA+bTUBB+kinesin-like KIF20A + AMPPNP – Cryo EM<br />
 
-
**[[6bbn]] - bTUBA+bTUBB+kinesin-like KIF2A + DARPIN + AMPPNP + GDP + GTP<br />
 
-
**[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br />
 
-
**[[5mm7]] - bTUBA1A+bTUBB +kinesin-4 motor domain + GTP + GDP + ANP + stabilizer – Cryo EM<br />
 
-
**[[5mm4]] - bTUBA1A+bTUBB +kinesin-5 motor domain + GTP + GDP + ANP + stabilizer – Cryo EM<br />
 
-
**[[5ogc]], [[5oam]] - bTUBA+pTUBB+kinesin-like KIF18A + GTP + GDP + stabilizer – Cryo EM<br />
 
-
**[[5ocu]] - bTUBA+pTUBB+kinesin-like KIF18A + GTP + GDP + ANP + stabilizer – Cryo EM<br />
 
-
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] - bTUBA1D+bTUBB2B+kinesin-5 motor domain + AMPPNP – Cryo EM<br />
 
-
**[[2hxf]], [[6b0c]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP - Cryo EM<br />
 
-
**[[3j6h]] - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM <br />
 
-
**[[3j8x]] - pTUBA+pTUBB +GDP + GTP + kinesin heavy chain – Cryo EM <br />
 
-
**[[3j8y]] - pTUBA+pTUBB +GDP + GTP + ATP + kinesin heavy chain – Cryo EM <br />
 
-
**[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br />
 
-
**[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br />
 
-
**[[6tiw]] - pTUBA+pTUBB+kinesin-like KIF11 + G2P + quinoline derivative – Cryo EM<br />
 
-
**[[6ta4]] - pTUBA+pTUBB+kinesin-like KIF11 + GTP + G2P + ANP – Cryo EM<br />
 
-
**[[6b0i]] - pTUBA+pTUBB+kinesin-like KLP10A + GTP + GDP + stabilizer – Cryo EM<br />
 
-
**[[6vpp]] - pTUBA+pTUBB+kinesin-like KLP61F + GTP + GDP – Cryo EM<br />
 
-
**[[6vpo]] - pTUBA+pTUBB+kinesin-like KLP61F + GTP + GDP + ANP – Cryo EM<br />
 
-
**[[6mlr]] - pTUBA+pTUBB+kinesin-like KIF7 + GTP + GDP + ANP + stabilizer – Cryo EM<br />
 
-
**[[6mlq]] - pTUBA+pTUBB+kinesin-like KIF7 + GTP + GDP + ADP + stabilizer – Cryo EM<br />
 
-
**[[6s8m]] - pTUBA+pTUBB+kinesin-like CUT7 + GTP + GDP + ANP – Cryo EM<br />
 
-
**[[6boi]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + stabilizer – Cryo EM<br />
 
-
**[[6b0l]] - pTUBA+pTUBB + kinesin-like KLP10A + GDP + GTP + AMPPNP + stabilizer – Cryo EM<br />
 
-
**[[4lnu]] - sTUBA+sTUBB + ankyrin repeat protein + GDP + GTP + kinesin heavy chain <br />
 
-
**[[5mlv]] - fyTUBA+ fyTUBB+kinesin-like CUT7 + GTP + GDP + ANP – fission yeast - Cryo EM<br />
 
-
**[[6u0h]] - TtTUBA+TUBB + GTP + GDP – ''Tetrahymena thermophila'' - Cryo EM<br />
 
-
**[[6u0u]], [[6u0t]] - TtTUBA+TUBB+ profilament ribbon protein + GTP + GDP - Cryo EM<br />
 
-
**[[5o09]] - PdTUBA+TUBB +GDP + GTP + kinesin light chain - Cryo EM <br />
 
- 
-
*α-tubulin + β-tubulin other complexes
 
- 
-
**[[6s8l]], [[6s8k]] - hTUBA+hTUBB + ankyrin repeat protein + GDP + GTP + plinabulin<br />
 
-
**[[6rza]] - hTUBA+hTUBB +GTP + GDP + stabilizer + dynein heavy chain – Cryo EM<br />
 
-
**[[6qvj]], [[6qus]] - hTUBA+hTUBB +GTP + GDP + stabilizer + CAMSAP1 – Cryo EM<br />
 
-
**[[6qve]] - hTUBA+hTUBB + GTP + GDP + stabilizer + protein – Cryo EM<br />
 
-
**[[6quy]] - hTUBA+hTUBB +GTP + GDP + stabilizer + CKK – Cryo EM<br />
 
-
**[[1tvk]] - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography<br />
 
-
**[[3iz0]] - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy<br />
 
-
**[[3j1t]], [[3j1u]] - bTUBA+bTUBB+ dynein<br />
 
-
**[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br />
 
-
**[[5itz]] - bTUBA+bTUBB + CENP-J + darpin + GTP + GDP + colchicine <br />
 
-
**[[5eib]] - bTUBA+bTUBB + CENP-J peptide + darpin + GTP + GDP<br />
 
-
**[[6kiq]], [[6kio]] - pTUBA+pTUBB + dynein heavy chain – Cryo EM<br />
 
-
**[[5nqu]], [[5nqt]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP<br />
 
-
**[[5nm5]] - bTUBA+bTUBB + ankyrin repeat protein + GDP + GTP + colchicine<br />
 
-
**[[5m50]], [[5m54]], [[5m5c]] - bTUBA+bTUBB + calmodulin-regulated spectrin-associated protein + GDP + GTP - Cryo EM<br />
 
-
**[[3j6p]], [[6rzb]] - pTUBA+pTUBB +GTP + GDP + stabilizer + dynein heavy chain – Cryo EM<br />
 
-
**[[3j6g]] - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM <br />
 
-
**[[6cvj]], [[6cvn]] - pTUBA+pTUBB + GTP + GDP + tau protein – Cryo EM <br />
 
-
**[[5kmg]] - pTUBA+pTUBB + protein regulator + GTP + GDP – Cryo EM <br />
 
-
**[[6mzg]], [[6mzf]], [[6mze]] - pTUBA+pTUBB + STU2P + darpin + GTP + GDP <br />
 
-
**[[5syg]], [[5syf]], [[5sye]], [[5syc]] - pTUBA+pTUBB + STU2P + stabilizer + GTP + GDP <br />
 
-
**[[6gx7]] - sTUBA+sTUBB + alpharep + low calcium response + GTP<br />
 
-
**[[6gwd]], [[6gwc]] - sTUBA+sTUBB + alpharep + GTP + GDP<br />
 
-
**[[6bjc]] - pTUBA+pTUBB + targeting protein for Xklp2 + GTP + GMPCPP – Cryo EM <br />
 
-
**[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br />
 
-
**[[4drx]] - sTUBA+sTUBB + ankyrin repeat protein<br />
 
-
**[[4ffb]], [[4u3j]] - yTUBA+TUBB (mutant) + protein STU2 <br />
 
-
**[[5mjs]] - fyTUBA+ fyTUBB + MAL3 + GTP + GDP + ANP - Cryo EM<br />
 
- 
-
*γ-tubulin
 
- 
-
**[[6v5v]] – hTUBG1 – Cryo EM<br />
 
-
**[[3cb2]] – hTUBG1+GDP<br />
 
-
**[[1z5v]] - hTUBG1+GTPgS<br />
 
-
**[[1z5w]] - hTUBG1+GTP<br />
 
-
**[[6v6b]] – hTUBG2 + TUBG3 – Cryo EM<br />
 
-
**[[3rip]] – hTUBG4<br />
 
-
**[[6v69]] – hTUBG4 + TUBG5 – Cryo EM<br />
 
-
**[[6v6c]] – hTUBG6 – Cryo EM<br />
 
- 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:03, 12 March 2020

γ-tubulin complex with GTP and Mg+2 ion (green), 1z5w

Drag the structure with the mouse to rotate

References

  1. ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
  2. ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
  3. ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
  4. ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Tubulin"
Personal tools