1arm

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[[Image:1arm.gif|left|200px]]
[[Image:1arm.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1arm |SIZE=350|CAPTION= <scene name='initialview01'>1arm</scene>, resolution 1.76&Aring;
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The line below this paragraph, containing "STRUCTURE_1arm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1arm| PDB=1arm | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1arm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1arm OCA], [http://www.ebi.ac.uk/pdbsum/1arm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1arm RCSB]</span>
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}}
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'''CARBOXYPEPTIDASE A WITH ZN REPLACED BY HG'''
'''CARBOXYPEPTIDASE A WITH ZN REPLACED BY HG'''
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[[Category: Shoham, G.]]
[[Category: Shoham, G.]]
[[Category: Tucker, P A.]]
[[Category: Tucker, P A.]]
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[[Category: carboxypeptidase]]
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[[Category: Carboxypeptidase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: metalloprotease]]
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[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:37:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:46:11 2008''
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Revision as of 07:37, 2 May 2008

Image:1arm.gif

Template:STRUCTURE 1arm

CARBOXYPEPTIDASE A WITH ZN REPLACED BY HG


Overview

The crystal structure of the zinc-containing exopeptidase bovine carboxypeptidase A (CPA) has been refined to high resolution, based on a data set collected from a single crystal, incorporating new sequence information based on cloning of the bovine gene. In addition, new refined structures are available for the zinc-removed form of the enzyme, apo-CPA, as well as the mercury-replaced form, Hg-CPA. The native structure reveals that the zinc-bound water molecule does not appear to more loosely bound than the rest of the zinc ligands, at least when B-factor values are considered. Nor is there any evidence for a secondary location of this water molecule. The apo-enzyme structure does not show any density in the place of the removed zinc ion. The only significant change appears to be a chi2 rotation of one zinc histidine ligand to form an ion-pair interaction with a glutamic acid side chain. The structure of Hg-CPA reveals a solvent Tris molecule bound to the mercury cation, as well as an unidentified cation bound to Glu270. The location of this citation agrees with previous proposals for the binding side of inhibitory zinc. These observations may explain some of the differences in kinetics observed in metal- replaced CPA.

About this Structure

1ARM is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Carboxypeptidase A: native, zinc-removed and mercury-replaced forms., Greenblatt HM, Feinberg H, Tucker PA, Shoham G, Acta Crystallogr D Biol Crystallogr. 1998 May 1;54(Pt 3):289-305. PMID:9867434 Page seeded by OCA on Fri May 2 10:37:28 2008

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