1aro

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[[Image:1aro.jpg|left|200px]]
[[Image:1aro.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1aro |SIZE=350|CAPTION= <scene name='initialview01'>1aro</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1aro", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10760 Enterobacteria phage T7])
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-->
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|DOMAIN=
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{{STRUCTURE_1aro| PDB=1aro | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aro OCA], [http://www.ebi.ac.uk/pdbsum/1aro PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aro RCSB]</span>
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}}
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'''T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME'''
'''T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME'''
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[[Category: Jeruzalmi, D.]]
[[Category: Jeruzalmi, D.]]
[[Category: Steitz, T.]]
[[Category: Steitz, T.]]
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[[Category: complex (polymerase/hydrolase)]]
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[[Category: Dna-directed rna polymerase]]
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[[Category: dna-directed rna polymerase]]
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[[Category: Glycosidase]]
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[[Category: glycosidase]]
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[[Category: Hydrolase]]
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[[Category: hydrolase]]
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[[Category: Transcription]]
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[[Category: transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:37:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:46:14 2008''
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Revision as of 07:37, 2 May 2008

Image:1aro.jpg

Template:STRUCTURE 1aro

T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME


Overview

The T7 RNA polymerase-T7 lysozyme complex regulates phage gene expression during infection of Escherichia coli. The 2.8 A crystal structure of the complex reveals that lysozyme binds at a site remote from the polymerase active site, suggesting an indirect mechanism of inhibition. Comparison of the T7 RNA polymerase structure with that of the homologous pol I family of DNA polymerases reveals identities in the catalytic site but also differences specific to RNA polymerase function. The structure of T7 RNA polymerase presented here differs significantly from a previously published structure. Sequence similarities between phage RNA polymerases and those from mitochondria and chloroplasts, when interpreted in the context of our revised model of T7 RNA polymerase, suggest a conserved fold.

About this Structure

1ARO is a Protein complex structure of sequences from Enterobacteria phage t7. Full crystallographic information is available from OCA.

Reference

Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme., Jeruzalmi D, Steitz TA, EMBO J. 1998 Jul 15;17(14):4101-13. PMID:9670025 Page seeded by OCA on Fri May 2 10:37:32 2008

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OCA

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