6hg9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II== | |
| - | + | <StructureSection load='6hg9' size='340' side='right'caption='[[6hg9]], [[Resolution|resolution]] 3.62Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HG9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hg4|6hg4]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hg9 OCA], [http://pdbe.org/6hg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hg9 RCSB], [http://www.ebi.ac.uk/pdbsum/6hg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hg9 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN]] Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:[http://omim.org/entry/613956 613956]]. CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref> [[http://www.uniprot.org/uniprot/I17RC_HUMAN I17RC_HUMAN]] Chronic mucocutaneous candidiasis. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN]] Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. [[http://www.uniprot.org/uniprot/I17RC_HUMAN I17RC_HUMAN]] Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).<ref>PMID:16785495</ref> <ref>PMID:17911633</ref> <ref>PMID:18684971</ref> Receptor for both IL17A and IL17F.<ref>PMID:16785495</ref> Does not bind IL17A or IL17F.<ref>PMID:16785495</ref> Does not bind IL17A or IL17F.<ref>PMID:16785495</ref> Receptor for both IL17A and IL17F.<ref>PMID:16785495</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Goepfert, A]] | ||
| + | [[Category: Rondeau, J M]] | ||
| + | [[Category: Cystine-knot]] | ||
| + | [[Category: Fniii domain]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Receptor-cytokine complex]] | ||
Revision as of 09:36, 18 March 2020
Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II
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