6hga

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'''Unreleased structure'''
 
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The entry 6hga is ON HOLD until Paper Publication
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==Crystal Structure of the human IL-17RC D2-D3-D4 domains in complex with an anti-APP tag Fab==
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<StructureSection load='6hga' size='340' side='right'caption='[[6hga]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hga]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HGA FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hg4|6hg4]], [[6hg9|6hg9]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hga OCA], [http://pdbe.org/6hga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hga RCSB], [http://www.ebi.ac.uk/pdbsum/6hga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hga ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/I17RC_HUMAN I17RC_HUMAN]] Chronic mucocutaneous candidiasis. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/I17RC_HUMAN I17RC_HUMAN]] Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).<ref>PMID:16785495</ref> <ref>PMID:17911633</ref> <ref>PMID:18684971</ref> Receptor for both IL17A and IL17F.<ref>PMID:16785495</ref> Does not bind IL17A or IL17F.<ref>PMID:16785495</ref> Does not bind IL17A or IL17F.<ref>PMID:16785495</ref> Receptor for both IL17A and IL17F.<ref>PMID:16785495</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Goepfert, A]]
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[[Category: Rondeau, J M]]
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[[Category: Fab complex]]
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[[Category: Fniii domain]]
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[[Category: Immune system]]

Revision as of 09:37, 18 March 2020

Crystal Structure of the human IL-17RC D2-D3-D4 domains in complex with an anti-APP tag Fab

PDB ID 6hga

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