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6hjl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Affimer:BclxL== | |
| - | + | <StructureSection load='6hjl' size='340' side='right'caption='[[6hjl]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hjl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjl OCA], [http://pdbe.org/6hjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hjl RCSB], [http://www.ebi.ac.uk/pdbsum/6hjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjl ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Edwards, T A]] | ||
| + | [[Category: Miles, J A]] | ||
| + | [[Category: Tomlinson, D C]] | ||
| + | [[Category: Trinh, C H]] | ||
| + | [[Category: Wilson, A J]] | ||
| + | [[Category: Affimer]] | ||
| + | [[Category: Protein binding]] | ||
Current revision
Affimer:BclxL
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