6oa6
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4== | |
| - | + | <StructureSection load='6oa6' size='340' side='right'caption='[[6oa6]], [[Resolution|resolution]] 1.37Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6oa6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OA6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OA6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6o31|6o31]], [[2r0o|2r0o]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oa6 OCA], [http://pdbe.org/6oa6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oa6 RCSB], [http://www.ebi.ac.uk/pdbsum/6oa6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oa6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ACTN4_HUMAN ACTN4_HUMAN]] Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:[http://omim.org/entry/603278 603278]]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:10700177</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACTN4_HUMAN ACTN4_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Birrane, G]] | ||
[[Category: Feng, D]] | [[Category: Feng, D]] | ||
| - | [[Category: | + | [[Category: Actin- binding protein]] |
| + | [[Category: Actin-crosslinking]] | ||
| + | [[Category: Calponin homology domain]] | ||
| + | [[Category: Ch domain]] | ||
| + | [[Category: Disease mutation]] | ||
| + | [[Category: Glomeruloscleros spectrin family]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: Phosphorylation]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 09:42, 18 March 2020
CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
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