6vps
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the amyloid core of Drosophila Orb2 isolated from head== | |
| - | + | <StructureSection load='6vps' size='340' side='right'caption='[[6vps]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vps]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VPS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vps OCA], [http://pdbe.org/6vps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vps RCSB], [http://www.ebi.ac.uk/pdbsum/6vps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vps ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ORB2_DROME ORB2_DROME]] Required in mushroom body gamma neurons for long-term memory in male courtship (PubMed:17965711, PubMed:23083740). Binds to mRNA 3'-UTRs (PubMed:20547833, PubMed:26638074, PubMed:24830287, PubMed:26095367). In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover (PubMed:20547833, PubMed:26638074). In its amyloid-like oligomeric form, acts as a translational activator (PubMed:26638074). The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA (PubMed:26638074). Isoform A is required for initial memory acquisition and, following subsequent late dopaminergic pathway activation, isoform A recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation (PubMed:26095367). Involved in asymmetric cell division in the central nervous system (PubMed:21900268). Required for the progression of spermatogenesis through meiosis and for sperm differentiation (PubMed:23209437). During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization (PubMed:24830287). Also required during spermatid cyst polarization for localization and translation of its own mRNA (PubMed:24830287).<ref>PMID:17965711</ref> <ref>PMID:20547833</ref> <ref>PMID:21900268</ref> <ref>PMID:23083740</ref> <ref>PMID:23209437</ref> <ref>PMID:24830287</ref> <ref>PMID:26095367</ref> <ref>PMID:26638074</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Drosophila melanogaster]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fitzpatrick, J A.J]] | ||
[[Category: Hervas, R]] | [[Category: Hervas, R]] | ||
| - | [[Category: | + | [[Category: Murzin, A G]] |
| - | [[Category: Rau, M | + | [[Category: Park, Y]] |
| + | [[Category: Rau, M J]] | ||
| + | [[Category: Scheres, S H.W]] | ||
[[Category: Si, K]] | [[Category: Si, K]] | ||
| - | [[Category: Scheres, S.H.W]] | ||
| - | [[Category: Murzin, A.G]] | ||
[[Category: Zhang, W]] | [[Category: Zhang, W]] | ||
| - | [[Category: | + | [[Category: Amyloid]] |
| + | [[Category: Long-term memory]] | ||
| + | [[Category: Prion-like]] | ||
| + | [[Category: Protein fibril]] | ||
Revision as of 10:01, 18 March 2020
Cryo-EM structure of the amyloid core of Drosophila Orb2 isolated from head
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