6y8m
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Fragment bikinin bound to Interleukin 1 beta== | |
| - | + | <StructureSection load='6y8m' size='340' side='right'caption='[[6y8m]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6y8m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Y8M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX2:4-[(5-BROMOPYRIDIN-2-YL)AMINO]-4-OXOBUTANOIC+ACID'>SX2</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6y8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y8m OCA], [http://pdbe.org/6y8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y8m RCSB], [http://www.ebi.ac.uk/pdbsum/6y8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y8m ProSAT]</span></td></tr> |
| - | [[Category: Nichols, C | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Nichols, C E]] | ||
| + | [[Category: Nicola, G F.De]] | ||
| + | [[Category: Fbdd]] | ||
| + | [[Category: Fragment based drug design]] | ||
| + | [[Category: Il1b]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Xchem]] | ||
Revision as of 10:04, 18 March 2020
Fragment bikinin bound to Interleukin 1 beta
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