5bzc
From Proteopedia
(Difference between revisions)
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==Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule== | ==Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule== | ||
| - | <StructureSection load='5bzc' size='340' side='right' caption='[[5bzc]], [[Resolution|resolution]] 1.95Å' scene=''> | + | <StructureSection load='5bzc' size='340' side='right'caption='[[5bzc]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5bzc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BZC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5bzc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BZC FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WT:4,4-DIMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE'>4WT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WT:4,4-DIMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE'>4WT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bzj|5bzj]], [[5bze|5bze]], [[5bzf|5bzf]], [[5bzg|5bzg]], [[5bzh|5bzh]], [[5bzi|5bzi]], [[5bzl|5bzl]], [[5bzm|5bzm]], [[5bzn|5bzn]], [[5bzo|5bzo]], [[5bzq|5bzq]], [[5bzp|5bzp]], [[5bzr|5bzr]], [[5bzs|5bzs]], [[5bzt|5bzt]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bzj|5bzj]], [[5bze|5bze]], [[5bzf|5bzf]], [[5bzg|5bzg]], [[5bzh|5bzh]], [[5bzi|5bzi]], [[5bzl|5bzl]], [[5bzm|5bzm]], [[5bzn|5bzn]], [[5bzo|5bzo]], [[5bzq|5bzq]], [[5bzp|5bzp]], [[5bzr|5bzr]], [[5bzs|5bzs]], [[5bzt|5bzt]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd44, Ly-24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bzc OCA], [http://pdbe.org/5bzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bzc RCSB], [http://www.ebi.ac.uk/pdbsum/5bzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bzc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bzc OCA], [http://pdbe.org/5bzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bzc RCSB], [http://www.ebi.ac.uk/pdbsum/5bzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bzc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE]] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing. | [[http://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE]] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing. | ||
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| + | ==See Also== | ||
| + | *[[CD44|CD44]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Finzel, B C]] | [[Category: Finzel, B C]] | ||
[[Category: Liu, L K]] | [[Category: Liu, L K]] | ||
[[Category: Link module]] | [[Category: Link module]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 11:04, 18 March 2020
Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule
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