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Uridine phosphorylase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The <scene name='59/596312/Cv/3'>active site of UPP contains the uracil product</scene><ref>PMID:22868762</ref>. Water molecule is shown as red sphere. | The <scene name='59/596312/Cv/3'>active site of UPP contains the uracil product</scene><ref>PMID:22868762</ref>. Water molecule is shown as red sphere. | ||
| + | == 3D Structures of uridine phosphorylase = | ||
| + | [[Uridine phosphorylase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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**[[1k3f]], [[1lx7]], [[1rxy]], [[1t0u]] – EcUPP – ''Escherichia coli'' <br /> | **[[1k3f]], [[1lx7]], [[1rxy]], [[1t0u]] – EcUPP – ''Escherichia coli'' <br /> | ||
**[[1ryz]], [[2iq5]], [[2oxf]], [[2qdk]], [[3dps]] – StUPP – ''Salmonella typhimurium'' <br /> | **[[1ryz]], [[2iq5]], [[2oxf]], [[2qdk]], [[3dps]] – StUPP – ''Salmonella typhimurium'' <br /> | ||
| - | **[[3o6v]], [[4k6o]] – VcUPP – ''Vibrio cholerae'' <br /> | + | **[[3o6v]], [[4k6o]], [[6eyp]] – VcUPP – ''Vibrio cholerae'' <br /> |
**[[4i2v]], [[4ny1]], [[4of4]] – UPP – ''Yersinia pseudotuberculosis''<br /> | **[[4i2v]], [[4ny1]], [[4of4]] – UPP – ''Yersinia pseudotuberculosis''<br /> | ||
**[[4txh]] – SmUPP – ''Schistosoma mansoni'' <br /> | **[[4txh]] – SmUPP – ''Schistosoma mansoni'' <br /> | ||
| + | **[[6k5g]], [[6k5h]], [[6k5k]], [[6k8p]], [[6kd3]] – UPP – ''Phytophthora capsici'' <br /> | ||
*Uridine phosphorylase binary complex | *Uridine phosphorylase binary complex | ||
| + | **[[3ku4]] – bUPP + sulfate - bovine <br /> | ||
**[[1sj9]], [[2hsw]], [[2i8a]], [[3ddo]] – StUPP + phosphate <br /> | **[[1sj9]], [[2hsw]], [[2i8a]], [[3ddo]] – StUPP + phosphate <br /> | ||
**[[1y1t]] – StUPP + sulfate <br /> | **[[1y1t]] – StUPP + sulfate <br /> | ||
**[[2oec]], [[3c74]] – StUPP + inhibitor<br /> | **[[2oec]], [[3c74]] – StUPP + inhibitor<br /> | ||
| - | **[[3ku4]] – bUPP + sulfate - bovine <br /> | ||
| - | **[[4e1v]], [[4ogk]], [[4ogl]] – SeUPP + nucleotide – ''Salmonella enterica''<br /> | ||
**[[4g8j]] – StUPP + 2’-deoxythymidine <br /> | **[[4g8j]] – StUPP + 2’-deoxythymidine <br /> | ||
| + | **[[4e1v]], [[4ogk]], [[4ogl]] – SeUPP + nucleotide – ''Salmonella enterica''<br /> | ||
**[[4lnh]] – VfUPP + sulfate – ''Vibrio fischeri'' <br /> | **[[4lnh]] – VfUPP + sulfate – ''Vibrio fischeri'' <br /> | ||
**[[4h1t]], [[4ip0]] – VcUPP + phosphate <br /> | **[[4h1t]], [[4ip0]] – VcUPP + phosphate <br /> | ||
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**[[5our]] – VcUPP + anhydrouridine <br /> | **[[5our]] – VcUPP + anhydrouridine <br /> | ||
**[[4lzw]], [[4oeh]], [[5c80]], [[5epu]], [[5efo]], [[5m2t]] – VcUPP + nucleotide <br /> | **[[4lzw]], [[4oeh]], [[5c80]], [[5epu]], [[5efo]], [[5m2t]] – VcUPP + nucleotide <br /> | ||
| - | **[[4txj]], [[4txl]], [[4txn]], [[4txm]] – SmUPP + nucleotide <br /> | ||
**[[4u2k]] – VcUPP + anticancer compound <br /> | **[[4u2k]] – VcUPP + anticancer compound <br /> | ||
| + | **[[4txj]], [[4txl]], [[4txn]], [[4txm]] – SmUPP + nucleotide <br /> | ||
**[[4jp5]] – UPP + sulfate – ''Yersinia pestis''<br /> | **[[4jp5]] – UPP + sulfate – ''Yersinia pestis''<br /> | ||
**[[4r2x]] – SoUPP + sulfate – ''Shewanella oneidensis''<br /> | **[[4r2x]] – SoUPP + sulfate – ''Shewanella oneidensis''<br /> | ||
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*Uridine phosphorylase ternary complex | *Uridine phosphorylase ternary complex | ||
| + | **[[3kuk]] – bUPP + sulfate + 2’-deoxyuridine <br /> | ||
| + | **[[3kvr]] – bUPP + sulfate + 5-fluorouracil <br /> | ||
| + | **[[3kvy]] – bUPP + sulfate + uracil <br /> | ||
**[[1y1r]], [[1zl2]], [[2pga]], [[3fwp]] – StUPP + phosphate + inhibitor<br /> | **[[1y1r]], [[1zl2]], [[2pga]], [[3fwp]] – StUPP + phosphate + inhibitor<br /> | ||
**[[2rj3]] – StUPP + phosphate + uracil <br /> | **[[2rj3]] – StUPP + phosphate + uracil <br /> | ||
**[[1y1s]] – StUPP + sulfate + uracil <br /> | **[[1y1s]] – StUPP + sulfate + uracil <br /> | ||
**[[1y1q]] – StUPP + sulfate + UMP <br /> | **[[1y1q]] – StUPP + sulfate + UMP <br /> | ||
| - | **[[1rxs]] – EcUPP + phosphate + 2’-deoxyuridine <br /> | ||
| - | **[[3kuk]] – bUPP + sulfate + 2’-deoxyuridine <br /> | ||
| - | **[[1rxu]] – EcUPP + phosphate + 2’-deoxythymidine <br /> | ||
**[[2hn9]], [[2hrd]] – StUPP + phosphate + thymine <br /> | **[[2hn9]], [[2hrd]] – StUPP + phosphate + thymine <br /> | ||
**[[2hwu]] – StUPP + phosphate + uridine <br /> | **[[2hwu]] – StUPP + phosphate + uridine <br /> | ||
| + | **[[1rxs]] – EcUPP + phosphate + 2’-deoxyuridine <br / | ||
| + | **[[1rxu]] – EcUPP + phosphate + 2’-deoxythymidine <br /> | ||
**[[1tgy]] – EcUPP + ribose-1-phosphate + uracil <br /> | **[[1tgy]] – EcUPP + ribose-1-phosphate + uracil <br /> | ||
| - | **[[3qpb]] – UPP + ribose-1-phosphate + uracil – ''Streptococcus pyogenes''<br /> | ||
**[[1u1c]], [[1u1d]], [[1u1e]], [[1u1f]], [[1u1g]] – EcUPP + phosphate + 5-substituted acyclouridine <br /> | **[[1u1c]], [[1u1d]], [[1u1e]], [[1u1f]], [[1u1g]] – EcUPP + phosphate + 5-substituted acyclouridine <br /> | ||
**[[1tgv]] – EcUPP + sulfate + 5-fluorouridine <br /> | **[[1tgv]] – EcUPP + sulfate + 5-fluorouridine <br /> | ||
**[[3kvv]] – EcUPP + sulfate + 5-fluorouracil <br /> | **[[3kvv]] – EcUPP + sulfate + 5-fluorouracil <br /> | ||
| - | **[[ | + | **[[1rxc]] – EcUPP + ribose-1-phosphate + phosphate + 5-fluorouracil + 5-fluorouridine <br /> |
| - | + | ||
**[[3pns]], [[5miw]] – VcUPP + sulfate + uracil <br /> | **[[3pns]], [[5miw]] – VcUPP + sulfate + uracil <br /> | ||
**[[5lhv]] – VcUPP + sulfate + uridine <br /> | **[[5lhv]] – VcUPP + sulfate + uridine <br /> | ||
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**[[4r2w]] – SoUPP + sulfate + uridine <br /> | **[[4r2w]] – SoUPP + sulfate + uridine <br /> | ||
**[[4yjk]] – SoUPP (mutant) + sulfate + uracil <br /> | **[[4yjk]] – SoUPP (mutant) + sulfate + uracil <br /> | ||
| - | **[[ | + | **[[3qpb]] – UPP + ribose-1-phosphate + uracil – ''Streptococcus pyogenes''<br /> |
*Human uridine phosphorylase | *Human uridine phosphorylase | ||
Revision as of 10:28, 23 March 2020
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3D Structures of uridine phosphorylase
Updated on 23-March-2020
References
- ↑ Pizzorno G, Cao D, Leffert JJ, Russell RL, Zhang D, Handschumacher RE. Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):133-44. PMID:12084455
- ↑ Renck D, Santos AA Jr, Machado P, Petersen GO, Lopes TG, Santos DS, Campos MM, Basso LA. Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis. Invest New Drugs. 2014 Dec;32(6):1301-7. doi: 10.1007/s10637-014-0135-0. Epub, 2014 Jul 23. PMID:25052233 doi:http://dx.doi.org/10.1007/s10637-014-0135-0
- ↑ Lashkov AA, Sotnichenko SE, Prokofiev II, Gabdulkhakov AG, Agapov II, Shtil AA, Betzel C, Mironov AS, Mikhailov AM. X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae. Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):968-74. Epub 2012 Jul 17. PMID:22868762 doi:http://dx.doi.org/10.1107/S090744491201815X
