Sandbox Reserved 1606

Introduction

The ABCG2 multidrug transporter is a membrane protein from the ATP-binding cassette (ABC) transporter family, specifically the G-subfamily. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, blood-testis, and maternal-fetal barriers.^[1] ABCG2 protects cells by exporting xenobiotic molecules out of the cell using ATP hydrolysis. ABCG2 also affects the pharmacokinetics of many drugs and contributes to multidrug resistance.^[2]

Function

Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue (expand a bit/maybe combine intro and function?) maybe explain the general mechanism here?

Structural highlights

Overall 3D Structure

picture of domains. NBD - binding site for atp Homodimer

ATP Bound and Unbound Conformations

FIGURE LEGEND

Cavities and Lysine Plug

Disease

Cancer

ABCG2 contributes to multidrug resistance in cancer cells by exporting anti-tumor drugs out of cells which is an obstacle in cancer treatment.^[1] brief description of the cancer genes listed in the papers (papers talk about how some cancers had more expression of abcg2 genes)

ABCG2 as a Target for Inhibition

Talk about how and why it would be a good target for the treatment of cancer

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.