User:Madison Summers/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 13: | Line 13: | ||
== Structural highlights == | == Structural highlights == | ||
| - | <scene name='83/837230/Selectivity_pore_space_fill/2'>Small pore, highly specific for calcium binding</scene> | + | |
| + | The MCU is a tetrameric uniporter with four fold rotational symmetry, forming a truncated pyramid. The uniporter has only a single strong binding site. The <scene name='83/837230/Selectivity_pore_space_fill/2'>Small pore, highly specific for calcium binding</scene> is located in the transmembrane domain, TM2. TM 1 surrounds the pore. | ||
| + | |||
</StructureSection> | </StructureSection> | ||
Revision as of 03:04, 24 March 2020
Mitochondrial Calcium Uniporter, E. coli
| |||||||||||
References
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
- ↑ Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY. Cryo-EM structure of a mitochondrial calcium uniporter. Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988 doi:http://dx.doi.org/10.1126/science.aar4056
Student Contributors
- Madison Summers
- Holly Rowe
- Lizzy Ratz
