User:Madison Summers/Sandbox 1
From Proteopedia
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=Mitochondrial Calcium Uniporter, ''E. coli''= | =Mitochondrial Calcium Uniporter, ''E. coli''= | ||
<StructureSection load='6DT0' size='350' frame='true' side='right' caption='Mitochondrial calcium uniporter 6Dt0' scene='83/837230/Selectivity_pore_space_fill/1'> | <StructureSection load='6DT0' size='350' frame='true' side='right' caption='Mitochondrial calcium uniporter 6Dt0' scene='83/837230/Selectivity_pore_space_fill/1'> | ||
| - | + | scene= | |
==Introduction== | ==Introduction== | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The MCU is a tetrameric uniporter with four fold rotational symmetry, forming a truncated pyramid. The uniporter has only a single strong binding site. The <scene name='83/837230/Selectivity_pore_space_fill/2'>Small pore, highly specific for calcium binding</scene> is located in the transmembrane domain, TM2 | + | The MCU is a tetrameric uniporter with four fold rotational symmetry, forming a truncated pyramid. The uniporter has only a single strong binding site. The <scene name='83/837230/Selectivity_pore_space_fill/2'>Small pore, highly specific for calcium binding</scene> is located in the <scene name='83/837230/Transmembrane_domain/1'>transmembrane domain</scene>, in TM2, on the inside and, while TM 1 surrounds the pore. |
Revision as of 03:39, 24 March 2020
Mitochondrial Calcium Uniporter, E. coli
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References
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
- ↑ Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY. Cryo-EM structure of a mitochondrial calcium uniporter. Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988 doi:http://dx.doi.org/10.1126/science.aar4056
Student Contributors
- Madison Summers
- Holly Rowe
- Lizzy Ratz
