Coronavirus Disease 2019 (COVID-19)
From Proteopedia
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<StructureSection load='6vsb' size='250' side='right' scene='83/839266/Covid-19_spike/7' caption='COVID-19 surface spike (PDB entry [[6vsb]])'> | <StructureSection load='6vsb' size='250' side='right' scene='83/839266/Covid-19_spike/7' caption='COVID-19 surface spike (PDB entry [[6vsb]])'> | ||
[[Image:COVID-19.jpeg|left|200px|thumb|COVID-19 (CDC/Eckert & Higgins)]] | [[Image:COVID-19.jpeg|left|200px|thumb|COVID-19 (CDC/Eckert & Higgins)]] | ||
- | A novel coronavirus was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. LEFT: Overall structure of the COVID-19 virus. Note the spikes that adorn the outer surface, | + | A novel coronavirus was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. LEFT: Overall structure of the COVID-19 virus. Note the spikes that adorn the outer surface, <span style="color:red">red</span>, which impart the look of a '''corona''' surrounding the virus. RIGHT: A close up view of these spikes from studies by McLellan lab<ref name="McLellan">PMID:32075877</ref>. An animation (by [http://elarasystems.com Elara Systems)] shows how [http://www.dropbox.com/s/24e5f5wdh64f5fv/ES_NL_CoronaVirus_Final.mp4?dl=0 COVID-19 interacts with its host], via these spikes, thus permitting its genome to enter the host (human) cell<ref name="McLellan" />. |
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Photo credit (to the left): Alissa Eckert, MS; Dan Higgins, MAMS | Photo credit (to the left): Alissa Eckert, MS; Dan Higgins, MAMS |
Revision as of 08:46, 24 March 2020
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References
- ↑ 1.0 1.1 1.2 Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020 Feb 19. pii: science.abb2507. doi: 10.1126/science.abb2507. PMID:32075877 doi:http://dx.doi.org/10.1126/science.abb2507
- ↑ Gordon, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing: bioRxiv (online) 2020 http://doi.org/10.1101/2020.03.22.002386
- ↑ Gautret, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open- label non-randomized clinical trial: Intl J Antimcrob Agents (in press) 2020 http://dx.doi.org/10.1016/j.ijantimicag.2020.105949
- ↑ Gao, et al. Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target: bioRxiv (online) 2020 https://doi.org/10.1101/2020.03.16.993386
- ↑ Jin, et al. Structure of Mpro from COVID-19 virus and discovery of its inhibitors: bioRxiv (online) 2020 http://doi.org/10.1101/2020.02.26.964882
- ↑ Andersen, et al. The proximal origin of SARS-CoV-2: Nature Med (in press) 2020 http://dx.doi.org/10.1038/s41591-020-0820-9]
- ↑ Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science. 2020 Mar 4. pii: science.abb2762. doi: 10.1126/science.abb2762. PMID:32132184 doi:http://dx.doi.org/10.1126/science.abb2762
- ↑ Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther. 2020;14(1):58-60. doi: 10.5582/ddt.2020.01012. PMID:32147628 doi:http://dx.doi.org/10.5582/ddt.2020.01012
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