User:Madison Summers/Sandbox 1

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== Structural highlights ==
== Structural highlights ==
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The MCU is a tetrameric truncated pyramid with only a single strong binding, site located in the selectivity pore, near the surface of the mitochondrial membrane. The <scene name='83/837230/Selectivity_pore_space_fill/2'>Small pore, highly specific for calcium binding</scene> is located in the <scene name='83/837230/Transmembrane_domain/1'>transmembrane domain</scene>, in TM2 while TM 1 surrounds the pore. Activity of the uniporter is dependent on membrane potential and calcium concentration. Calcium from the cytoplasm entrees the mitochondrial innermemnrane space through the mitochondrial membrane and is passed to the mitochondrial matrix via the MCU. [[Image:Screen Shot 2020-03-23 at 10.47.18 PM]]
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The MCU is a tetrameric truncated pyramid with only a single strong binding, site located in the selectivity pore, near the surface of the mitochondrial membrane. The <scene name='83/837230/Selectivity_pore_space_fill/2'>Small pore, highly specific for calcium binding</scene> is located in the <scene name='83/837230/Transmembrane_domain/1'>transmembrane domain</scene>, in TM2 while TM 1 surrounds the pore. Activity of the uniporter is dependent on membrane potential and calcium concentration. Calcium from the cytoplasm entrees the mitochondrial innermemnrane space through the mitochondrial membrane and is passed to the mitochondrial matrix via the MCU. [[Image:structure.png|300 px|right|thumb|Figure 2]]

Revision as of 13:56, 24 March 2020

Mitochondrial Calcium Uniporter, E. coli

Mitochondrial calcium uniporter 6Dt0

Drag the structure with the mouse to rotate

References

[1] [2]

  1. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
  2. ↑ Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY. Cryo-EM structure of a mitochondrial calcium uniporter. Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988 doi:http://dx.doi.org/10.1126/science.aar4056

Student Contributors

  • Madison Summers
  • Holly Rowe
  • Lizzy Ratz

Proteopedia Page Contributors and Editors (what is this?)

Madison Summers

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