1au6
From Proteopedia
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'''SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE''' | '''SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU6 OCA]. | |
==Reference== | ==Reference== | ||
A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA., Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH, Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7664126 7664126] | A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA., Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH, Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7664126 7664126] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Boom, J H.Van.]] | [[Category: Boom, J H.Van.]] | ||
[[Category: Boom, S S.G E.Van.]] | [[Category: Boom, S S.G E.Van.]] | ||
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[[Category: Wang, A H.J.]] | [[Category: Wang, A H.J.]] | ||
[[Category: Yang, D.]] | [[Category: Yang, D.]] | ||
| - | [[Category: | + | [[Category: Deoxyribonucleic acid]] |
| - | + | [[Category: Dna]] | |
| - | [[Category: | + | [[Category: Dumbbell structure]] |
| - | [[Category: | + | [[Category: Interstrand crosslink]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:41:42 2008'' |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:41, 2 May 2008
SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE
Overview
The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds.
About this Structure
Full crystallographic information is available from OCA.
Reference
A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA., Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH, Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126 Page seeded by OCA on Fri May 2 10:41:42 2008
