1aum
From Proteopedia
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'''HIV CAPSID C-TERMINAL DOMAIN (CAC146)''' | '''HIV CAPSID C-TERMINAL DOMAIN (CAC146)''' | ||
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[[Category: Worthylake, D K.]] | [[Category: Worthylake, D K.]] | ||
[[Category: Yoo, S.]] | [[Category: Yoo, S.]] | ||
| - | [[Category: | + | [[Category: C-terminal domain]] |
| - | [[Category: | + | [[Category: Cac146]] |
| - | [[Category: | + | [[Category: Capsid]] |
| - | [[Category: | + | [[Category: Core protein]] |
| - | [[Category: | + | [[Category: Hiv]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:42:43 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:42, 2 May 2008
HIV CAPSID C-TERMINAL DOMAIN (CAC146)
Overview
The carboxyl-terminal domain, residues 146 to 231, of the human immunodeficiency virus-1 (HIV-1) capsid protein [CA(146-231)] is required for capsid dimerization and viral assembly. This domain contains a stretch of 20 residues, called the major homology region (MHR), which is conserved across retroviruses and is essential for viral assembly, maturation, and infectivity. The crystal structures of CA(146-231) and CA(151-231) reveal that the globular domain is composed of four helices and an extended amino-terminal strand. CA(146-231) dimerizes through parallel packing of helix 2 across a dyad. The MHR is distinct from the dimer interface and instead forms an intricate hydrogen-bonding network that interconnects strand 1 and helices 1 and 2. Alignment of the CA(146-231) dimer with the crystal structure of the capsid amino-terminal domain provides a model for the intact protein and extends models for assembly of the central conical core of HIV-1.
About this Structure
1AUM is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein., Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP, Science. 1997 Oct 31;278(5339):849-53. PMID:9346481 Page seeded by OCA on Fri May 2 10:42:43 2008
