1auq
From Proteopedia
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'''A1 DOMAIN OF VON WILLEBRAND FACTOR''' | '''A1 DOMAIN OF VON WILLEBRAND FACTOR''' | ||
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[[Category: Handin, R.]] | [[Category: Handin, R.]] | ||
[[Category: Liddington, R.]] | [[Category: Liddington, R.]] | ||
| - | [[Category: | + | [[Category: Blood coagulation]] |
| - | [[Category: | + | [[Category: Glycoprotein]] |
| - | [[Category: | + | [[Category: Platelet]] |
| - | [[Category: | + | [[Category: Willebrand]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:42:55 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:42, 2 May 2008
A1 DOMAIN OF VON WILLEBRAND FACTOR
Overview
von Willebrand Factor (vWF) is a multimeric protein that mediates platelet adhesion to exposed subendothelium at sites of vascular injury under conditions of high flow/shear. The A1 domain of vWF (vWF-A1) forms the principal binding site for platelet glycoprotein Ib (GpIb), an interaction that is tightly regulated. We report here the crystal structure of the vWF-A1 domain at 2.3-A resolution. As expected, the overall fold is similar to that of the vWF-A3 and integrin I domains. However, the structure also contains N- and C-terminal arms that wrap across the lower surface of the domain. Unlike the integrin I domains, vWF-A1 does not contain a metal ion-dependent adhesion site motif. Analysis of the available mutagenesis data suggests that the activator botrocetin binds to the right-hand face of the domain containing helices alpha5 and alpha6. Possible binding sites for GpIb are the front and upper surfaces of the domain. Natural mutations that lead to constitutive GpIb binding (von Willebrand type IIb disease) cluster in a different site, at the interface between the lower surface and the terminal arms, suggesting that they disrupt a regulatory region rather than forming part of the primary GpIb binding site. A possible pathway for propagating structural changes from the regulatory region to the ligand-binding surface is discussed.
About this Structure
1AUQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib., Emsley J, Cruz M, Handin R, Liddington R, J Biol Chem. 1998 Apr 24;273(17):10396-401. PMID:9553097 Page seeded by OCA on Fri May 2 10:42:55 2008
