6lpf
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of human cytoplasmic LRS== |
| - | + | <StructureSection load='6lpf' size='340' side='right'caption='[[6lpf]], [[Resolution|resolution]] 2.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6lpf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LPF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LSS:5-O-(L-LEUCYLSULFAMOYL)ADENOSINE'>LSS</scene>, <scene name='pdbligand=VRT:2-(L-NORVALYL)AMINO-2-DEOXYADENOSINE'>VRT</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lpf OCA], [http://pdbe.org/6lpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lpf RCSB], [http://www.ebi.ac.uk/pdbsum/6lpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lpf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN]] Acute infantile liver failure-multisystemic involvement syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN]] Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.<ref>PMID:19426743</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Leucine--tRNA ligase]] | ||
| + | [[Category: Cusack, S]] | ||
| + | [[Category: Li, H]] | ||
| + | [[Category: Li, J]] | ||
| + | [[Category: Lin, J Z]] | ||
| + | [[Category: Liu, R J]] | ||
| + | [[Category: Long, T]] | ||
| + | [[Category: Palencia, A]] | ||
| + | [[Category: Wang, E D]] | ||
| + | [[Category: Wang, M Z]] | ||
| + | [[Category: Zhao, J H]] | ||
| + | [[Category: Aminoacylation]] | ||
| + | [[Category: Leur]] | ||
| + | [[Category: Protein translation]] | ||
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Trna]] | ||
Revision as of 10:09, 27 March 2020
The crystal structure of human cytoplasmic LRS
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Categories: Large Structures | Leucine--tRNA ligase | Cusack, S | Li, H | Li, J | Lin, J Z | Liu, R J | Long, T | Palencia, A | Wang, E D | Wang, M Z | Zhao, J H | Aminoacylation | Leur | Protein translation | Rna binding protein | Trna
