6u3t
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus== | |
| - | + | <StructureSection load='6u3t' size='340' side='right'caption='[[6u3t]], [[Resolution|resolution]] 2.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6u3t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U3T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PQJ:fos-choline-14'>PQJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3t OCA], [http://pdbe.org/6u3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3t RCSB], [http://www.ebi.ac.uk/pdbsum/6u3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3t ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU]] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kozhaya, L]] | ||
| + | [[Category: Liu, J]] | ||
[[Category: Lu, M]] | [[Category: Lu, M]] | ||
| + | [[Category: Torres, V J]] | ||
[[Category: Unutmaz, D]] | [[Category: Unutmaz, D]] | ||
| - | [[Category: | + | [[Category: Alpha-toxin]] |
| - | [[Category: | + | [[Category: Leukocidin]] |
| - | [[Category: | + | [[Category: Mrsa]] |
| + | [[Category: Pvl]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 10:20, 27 March 2020
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
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Categories: Large Structures | Kozhaya, L | Liu, J | Lu, M | Torres, V J | Unutmaz, D | Alpha-toxin | Leukocidin | Mrsa | Pvl | Toxin
