6vro
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of the PP2A B56 subunit AIM1 complex== |
| - | + | <StructureSection load='6vro' size='340' side='right'caption='[[6vro]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vro]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VRO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vro OCA], [http://pdbe.org/6vro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vro RCSB], [http://www.ebi.ac.uk/pdbsum/6vro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vro ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref> [[http://www.uniprot.org/uniprot/CRBG1_HUMAN CRBG1_HUMAN]] May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Page, R]] | ||
| + | [[Category: Peti, W]] | ||
| + | [[Category: Wang, X]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Ser/thr phosphatase]] | ||
Revision as of 10:24, 27 March 2020
The structure of the PP2A B56 subunit AIM1 complex
| |||||||||||
