6vyc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of WD-repeat domain of human WDR91== | |
| - | + | <StructureSection load='6vyc' size='340' side='right'caption='[[6vyc]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vyc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VYC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyc OCA], [http://pdbe.org/6vyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vyc RCSB], [http://www.ebi.ac.uk/pdbsum/6vyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyc ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN]] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Halabelian, L]] | ||
[[Category: Hutchinson, A]] | [[Category: Hutchinson, A]] | ||
| - | [[Category: | + | [[Category: Li, Y]] |
| + | [[Category: Structural genomic]] | ||
[[Category: Seitova, A]] | [[Category: Seitova, A]] | ||
| - | [[Category: | + | [[Category: Protein transport]] |
| - | [[Category: | + | [[Category: Sgc]] |
| - | [[Category: | + | [[Category: Wd-repeat]] |
| - | + | [[Category: Wdr91]] | |
| - | [[Category: | + | |
Revision as of 10:24, 27 March 2020
Crystal structure of WD-repeat domain of human WDR91
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