1av1
From Proteopedia
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'''CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I''' | '''CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I''' | ||
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[[Category: Engler, J A.]] | [[Category: Engler, J A.]] | ||
[[Category: Rogers, D P.]] | [[Category: Rogers, D P.]] | ||
| - | [[Category: | + | [[Category: Atherosclerosis]] |
| - | [[Category: | + | [[Category: Cholesterol metabolism]] |
| - | [[Category: | + | [[Category: Hdl]] |
| - | [[Category: | + | [[Category: Lcat-activation]] |
| - | [[Category: | + | [[Category: Lipid transport]] |
| - | [[Category: | + | [[Category: Lipoprotein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:43:31 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:43, 2 May 2008
CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I
Overview
The structure of truncated human apolipoprotein A-I (apo A-I), the major protein component of high density lipoprotein, has been determined at 4-A resolution. The crystals comprise residues 44-243 (exon 4) of apo A-I, a fragment that binds to lipid similarly to intact apo A-I and that retains the lipid-bound conformation even in the absence of lipid. The molecule consists almost entirely of a pseudo-continuous, amphipathic alpha-helix that is punctuated by kinks at regularly spaced proline residues; it adopts a shape similar to a horseshoe of dimensions 125 x 80 x 40 A. Four molecules in the asymmetric unit associate via their hydrophobic faces to form an antiparallel four-helix bundle with an elliptical ring shape. Based on this structure, we propose a model for the structure of apo A-I bound to high density lipoprotein.
About this Structure
1AV1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation., Borhani DW, Rogers DP, Engler JA, Brouillette CG, Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12291-6. PMID:9356442 Page seeded by OCA on Fri May 2 10:43:31 2008
