This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5cb4
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of T2R-TTL-Tivantinib complex== | ==Crystal structure of T2R-TTL-Tivantinib complex== | ||
| - | <StructureSection load='5cb4' size='340' side='right' caption='[[5cb4]], [[Resolution|resolution]] 2.19Å' scene=''> | + | <StructureSection load='5cb4' size='340' side='right'caption='[[5cb4]], [[Resolution|resolution]] 2.19Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5cb4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Sus_barbatus Sus barbatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CB4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5cb4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat], [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Sus_barbatus Sus barbatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CB4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TIV:(3R,4R)-3-(5,6-DIHYDRO-4H-PYRROLO[3,2,1-IJ]QUINOLIN-1-YL)-4-(1H-INDOL-3-YL)PYRROLIDINE-2,5-DIONE'>TIV</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TIV:(3R,4R)-3-(5,6-DIHYDRO-4H-PYRROLO[3,2,1-IJ]QUINOLIN-1-YL)-4-(1H-INDOL-3-YL)PYRROLIDINE-2,5-DIONE'>TIV</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c8y|5c8y]], [[5ca0|5ca0]], [[5ca1|5ca1]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c8y|5c8y]], [[5ca0|5ca0]], [[5ca1|5ca1]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cb4 OCA], [http://pdbe.org/5cb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cb4 RCSB], [http://www.ebi.ac.uk/pdbsum/5cb4 PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cb4 OCA], [http://pdbe.org/5cb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cb4 RCSB], [http://www.ebi.ac.uk/pdbsum/5cb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cb4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 18: | Line 20: | ||
</div> | </div> | ||
<div class="pdbe-citations 5cb4" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5cb4" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Stathmin-4 3D structures|Stathmin-4 3D structures]] | ||
| + | *[[Tubulin 3D Structures|Tubulin 3D Structures]] | ||
| + | *[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]] | ||
| + | *[[User:Alisa Cario|User:Alisa Cario]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Buffalo rat]] | ||
| + | [[Category: Chick]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Sus barbatus]] | [[Category: Sus barbatus]] | ||
[[Category: Chen, Q]] | [[Category: Chen, Q]] | ||
Revision as of 11:30, 27 March 2020
Crystal structure of T2R-TTL-Tivantinib complex
| |||||||||||
Categories: Buffalo rat | Chick | Large Structures | Sus barbatus | Chen, Q | Wang, Y | Yang, J | Yu, Y | Complex | Inhibitor | Structural protein | Tubulin
