5cgj
From Proteopedia
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==Crystal structure of murine Keap1 in complex with RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling.== | ==Crystal structure of murine Keap1 in complex with RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling.== | ||
| - | <StructureSection load='5cgj' size='340' side='right' caption='[[5cgj]], [[Resolution|resolution]] 3.36Å' scene=''> | + | <StructureSection load='5cgj' size='340' side='right'caption='[[5cgj]], [[Resolution|resolution]] 3.36Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5cgj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CGJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5cgj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CGJ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=51M:(3S)-1-(4-{[(2,3,5,6-TETRAMETHYLPHENYL)SULFONYL]AMINO}NAPHTHALEN-1-YL)PYRROLIDINE-3-CARBOXYLIC+ACID'>51M</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=51M:(3S)-1-(4-{[(2,3,5,6-TETRAMETHYLPHENYL)SULFONYL]AMINO}NAPHTHALEN-1-YL)PYRROLIDINE-3-CARBOXYLIC+ACID'>51M</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cgj OCA], [http://pdbe.org/5cgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cgj RCSB], [http://www.ebi.ac.uk/pdbsum/5cgj PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Keap1, Inrf2, Kiaa0132 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cgj OCA], [http://pdbe.org/5cgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cgj RCSB], [http://www.ebi.ac.uk/pdbsum/5cgj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cgj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5cgj" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5cgj" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Engel, C K]] | [[Category: Engel, C K]] | ||
[[Category: Loenze, P]] | [[Category: Loenze, P]] | ||
Revision as of 11:37, 27 March 2020
Crystal structure of murine Keap1 in complex with RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling.
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