1avf

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[[Image:1avf.gif|left|200px]]
[[Image:1avf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1avf |SIZE=350|CAPTION= <scene name='initialview01'>1avf</scene>, resolution 2.36&Aring;
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The line below this paragraph, containing "STRUCTURE_1avf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Gastricsin Gastricsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.3 3.4.23.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1avf| PDB=1avf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1avf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1avf OCA], [http://www.ebi.ac.uk/pdbsum/1avf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1avf RCSB]</span>
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}}
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'''ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH'''
'''ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH'''
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[[Category: Khan, A R.]]
[[Category: Khan, A R.]]
[[Category: Tarasova, N I.]]
[[Category: Tarasova, N I.]]
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[[Category: acid]]
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[[Category: Acid]]
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[[Category: activation]]
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[[Category: Activation]]
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[[Category: aspartic proteinase]]
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[[Category: Aspartic proteinase]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: gastricsin]]
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[[Category: Gastricsin]]
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[[Category: intermediate]]
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[[Category: Intermediate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:44:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:48:17 2008''
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Revision as of 07:44, 2 May 2008

Image:1avf.gif

Template:STRUCTURE 1avf

ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH


Overview

The crystal structure of an activation intermediate of human gastricsin has been determined at 2.4 A resolution. The human digestive enzyme gastricsin (pepsin C) is an aspartic proteinase that is synthesized as the inactive precursor (zymogen) progastricsin (pepsinogen C or hPGC). In the zymogen, a positively-charged N-terminal prosegment of 43 residues (Ala 1p-Leu 43p; the suffix 'p' refers to the prosegment) sterically prevents the approach of a substrate to the active site. Zymogen conversion occurs in an autocatalytic and stepwise fashion at low pH through the formation of intermediates. The structure of the non-covalent complex of a partially-cleaved peptide of the prosegment (Ala 1p-Phe 26p) with mature gastricsin (Ser 1-Ala 329) suggests an activation pathway that may be common to all gastric aspartic proteinases.

About this Structure

1AVF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin., Khan AR, Cherney MM, Tarasova NI, James MN, Nat Struct Biol. 1997 Dec;4(12):1010-5. PMID:9406551 Page seeded by OCA on Fri May 2 10:44:28 2008

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