User:Madison Summers/Sandbox 1
From Proteopedia
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The MCU is a dimer of dimers, described as tetrameric truncated pyramid. The uniporter has only a single strong binding site located in the selectivity pore, near the surface of the inner mitochondrial membrane. Activity of the uniporter is dependent on membrane potential and calcium concentration. Calcium from the cytoplasm enters the mitochondrial innermemnrane space through the mitochondrial membrane and is passed to the mitochondrial matrix via the MCU. [[Image:structure.png|300 px|right|thumb|Figure 2]] | The MCU is a dimer of dimers, described as tetrameric truncated pyramid. The uniporter has only a single strong binding site located in the selectivity pore, near the surface of the inner mitochondrial membrane. Activity of the uniporter is dependent on membrane potential and calcium concentration. Calcium from the cytoplasm enters the mitochondrial innermemnrane space through the mitochondrial membrane and is passed to the mitochondrial matrix via the MCU. [[Image:structure.png|300 px|right|thumb|Figure 2]] | ||
| + | ===Transmembrane Domain=== | ||
The <scene name='83/837230/Selectivity_pore_space_fill/2'>Small pore, highly specific for calcium binding</scene> is located in the <scene name='83/837230/Transmembrane_domain/1'>transmembrane domain</scene>, in TM2 (transmembrane 2) while TM 1 (transmembrane 1) surrounds the pore. The transmembrane domain exhibits four fold rotational symmetry. The domain swapping of TM1 of one subunit tightly packing with the TM2 of the neighboring subunits. | The <scene name='83/837230/Selectivity_pore_space_fill/2'>Small pore, highly specific for calcium binding</scene> is located in the <scene name='83/837230/Transmembrane_domain/1'>transmembrane domain</scene>, in TM2 (transmembrane 2) while TM 1 (transmembrane 1) surrounds the pore. The transmembrane domain exhibits four fold rotational symmetry. The domain swapping of TM1 of one subunit tightly packing with the TM2 of the neighboring subunits. | ||
| + | ===Coiled coil=== | ||
| + | |||
| + | ===N-terminal Domain=== | ||
Revision as of 16:52, 28 March 2020
Mitochondrial Calcium Uniporter, E. coli
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References
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
- ↑ Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY. Cryo-EM structure of a mitochondrial calcium uniporter. Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988 doi:http://dx.doi.org/10.1126/science.aar4056
Student Contributors
- Madison Summers
- Holly Rowe
- Lizzy Ratz
