Tyrosine kinase receptor

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Revision as of 10:04, 29 March 2020

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image describing Jmol [1] to the rescue. Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Tyrosine kinase receptor or high affinity nerve growth factor receptor (TRK-A) Disease Relevance TRK-A inhibitors are suitable alternatives to teatment of neoendocrine tumors like pheochromocytomas and [2]. Structural highlights

3D Structures tyrosine kinase receptor

Updated on 29-March-2020

• Tyrosine kinase receptor or high affinity nerve growth factor receptor; Domains – extracellular 36-382; LBD 285-380; transmembrane 410-447; kinase 498-796

1he7 – hTRK-A LBD domain – human
4crp – hTRK-A LBD domain (mutant) – NMR
2ifg – hTRK-A extracellular domain + b-nerve growth factor
[[4gt5], 4f0i] – hTRK-A kinase domain
5kvt, 6pl1, 6npt, 6nsp, 6nss, 5wr7, 6d1y, 6d1z, 6pmc, 6iqn, 6pl2, 6pl3, 6pma, 6pmb, 6pme, 5kmj, 5kmk, 5kmm, 5kmn, 5kmo, 4aoj, 4pmm, 4pmp, 4pms, 4pmt, 4yps, 5h3q, 5i8a, 5kmi, 5kml, 6d20, 6dkb, 6dkg, 6dki, 6j5l, 5jfs, 5jfv, 5jfw, 5jfx, 4yne, 6dkw – hTRK-A kinase domain + inhibitor
2n90 – hTRK-A transmembrane domain - NMR

References

1. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
2. ↑ Cassol CA, Winer D, Liu W, Guo M, Ezzat S, Asa SL. Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas. Mod Pathol. 2014 Aug;27(8):1050-62. doi: 10.1038/modpathol.2013.233. Epub 2014, Jan 3. PMID:24390213 doi:http://dx.doi.org/10.1038/modpathol.2013.233