Tyrosine kinase receptor
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> describing Jmol <ref>PMID:21638687</ref> to the rescue. == Function == '''Tyrosine k...) |
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| - | + | <StructureSection load='6p11' size='340' side='right' caption='Human TRK-A kinase domain complex with inhibitor (PDB code [[6p11]])' scene=''> | |
| - | <StructureSection load=' | + | |
describing Jmol <ref>PMID:21638687</ref> to the rescue. | describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
| - | '''Tyrosine kinase receptor''' or '''high affinity nerve growth factor receptor''' (TRK-A) | + | '''Tyrosine kinase receptor''' or '''high affinity nerve growth factor receptor''' (TRK-A) play an important role in cellular processes like growth, motility, differentiation and metabolism<ref>PMID:29455648</ref>. |
== Disease == | == Disease == | ||
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| + | Disregulation of TRK-A signalling leads to cancer. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | + | TRK-A contains an extracellular ligand binding domain (LBD), a transmembrane helix and an intracellular region which contains the kinase domain. | |
</StructureSection> | </StructureSection> | ||
Revision as of 10:23, 29 March 2020
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3D Structures tyrosine kinase receptor
Updated on 29-March-2020
- Tyrosine kinase receptor or high affinity nerve growth factor receptor; Domains – extracellular 36-382; LBD 285-380; transmembrane 410-447; kinase 498-796
1he7 – hTRK-A LBD domain – human
4crp – hTRK-A LBD domain (mutant) – NMR
2ifg – hTRK-A extracellular domain + b-nerve growth factor
[[4gt5], 4f0i] – hTRK-A kinase domain
5kvt, 6pl1, 6npt, 6nsp, 6nss, 5wr7, 6d1y, 6d1z, 6pmc, 6iqn, 6pl2, 6pl3, 6pma, 6pmb, 6pme, 5kmj, 5kmk, 5kmm, 5kmn, 5kmo, 4aoj, 4pmm, 4pmp, 4pms, 4pmt, 4yps, 5h3q, 5i8a, 5kmi, 5kml, 6d20, 6dkb, 6dkg, 6dki, 6j5l, 5jfs, 5jfv, 5jfw, 5jfx, 4yne, 6dkw – hTRK-A kinase domain + inhibitor
2n90 – hTRK-A transmembrane domain - NMR
References
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Du Z, Lovly CM. Mechanisms of receptor tyrosine kinase activation in cancer. Mol Cancer. 2018 Feb 19;17(1):58. doi: 10.1186/s12943-018-0782-4. PMID:29455648 doi:http://dx.doi.org/10.1186/s12943-018-0782-4
- ↑ Cassol CA, Winer D, Liu W, Guo M, Ezzat S, Asa SL. Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas. Mod Pathol. 2014 Aug;27(8):1050-62. doi: 10.1038/modpathol.2013.233. Epub 2014, Jan 3. PMID:24390213 doi:http://dx.doi.org/10.1038/modpathol.2013.233
