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Mitochondrial Calcium Uniporter, E. coli

spinqualitylabelsall models Mitochondrial calcium uniporter 6Dt0 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image scene= Contents 1 Introduction 1.1 selectivity pore 2 Disease 3 Relevance 4 Structural highlights and mechanism 4.1 Transmembrane Domain 4.2 Coiled coil 4.3 N-terminal Domain Introduction selectivity pore Disease Relevance Calcium signaling Structural highlights and mechanism The MCU is a dimer of dimers, described as tetrameric truncated pyramid. The uniporter has only a single strong binding site located in the selectivity pore, near the surface of the inner mitochondrial membrane. Activity of the uniporter is dependent on membrane potential and calcium concentration. Calcium from the cytoplasm enters the mitochondrial innermemnrane space through the mitochondrial membrane and is passed to the mitochondrial matrix via the MCU. Figure 2 Transmembrane Domain The is located in the , in TM2 (transmembrane 2) while TM 1 (transmembrane 1) surrounds the pore. The transmembrane domain exhibits four fold rotational symmetry. The domain swapping of TM1 of one subunit tightly packing with the TM2 of the neighboring subunits. Coiled coil N-terminal Domain

References

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1. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
2. ↑ Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY. Cryo-EM structure of a mitochondrial calcium uniporter. Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988 doi:http://dx.doi.org/10.1126/science.aar4056

Student Contributors

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